Sacubitril CAS# 149709-62-6 沙库比曲
Sacubitril, also known as AHU377, is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.
📌 参考资料/链接：
Reference: Zhang, Bo; Ding, Xiaohua; Dai, Dongcheng; Lei, Sijun; Liu, Xueming; Duan, Panpan; Chen, Yongkai; Wang, Chaodong. Preparation of crystal form and amorphous form of AHU-377 ammonium salt. WO 2018196860. (Wuhan Ll Science and Technology Development Co., Ltd., Peop. Rep. China; Wuhan Qr Pharmaceuticals Co., Ltd)
Reference: Zhang, Bo; Ding, Xiaohua; Dai, Dongcheng; Lei, Sijun; Liu, Xueming; Duan, Panpan; Chen, Yongkai; Wang, Chaodong. Preparation of crystal form and amorphous form of AHU-377 ammonium salt. WO 2018196860. (Wuhan Ll Science and Technology Development Co., Ltd., Peop. Rep. China; Wuhan Qr Pharmaceuticals Co., Ltd)
📄 详细内容
CAS No. 149709-62-6 沙库比曲Sacubitril synthetic routes
Zhang, Bo; Ding, Xiaohua; Dai, Dongcheng; Lei, Sijun; Liu, Xueming; Duan, Panpan; Chen, Yongkai; Wang, Chaodong. Preparation of crystal form and amorphous form of AHU-377 ammonium salt. WO 2018196860. (Wuhan Ll Science and Technology Development Co., Ltd., Peop. Rep. China; Wuhan Qr Pharmaceuticals Co., Ltd)
产品链接: CAS No. 149709-62-6 ››
Zhang, Bo; Ding, Xiaohua; Dai, Dongcheng; Lei, Sijun; Liu, Xueming; Duan, Panpan; Chen, Yongkai; Wang, Chaodong. Preparation of crystal form and amorphous form of AHU-377 ammonium salt. WO 2018196860. (Wuhan Ll Science and Technology Development Co., Ltd., Peop. Rep. China; Wuhan Qr Pharmaceuticals Co., Ltd)
产品链接: CAS No. 149709-62-6 ››