Pralatrexate CAS# 146464-95-1 普拉曲沙
Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylated and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis, which may result in depletion of nucleotide precursors; inhibition of DNA, RNA and protein synthesis; and apoptotic tumor cell death.
📌 参考资料/链接：
DeGraw, Joseph I.; Colwell, William T.; Piper, James R.; Sirotnak, Francis M. Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin. Journal of Medicinal Chemistry. Volume 36. Issue 15. Pages 2228-31. 1993.
DeGraw, Joseph I.; Colwell, William T.; Piper, James R.; Sirotnak, Francis M. Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin. Journal of Medicinal Chemistry. Volume 36. Issue 15. Pages 2228-31. 1993.
📄 详细内容
CAS No. 146464-95-1 普拉曲沙Pralatrexate synthetic routes
DeGraw, Joseph I.; Colwell, William T.; Piper, James R.; Sirotnak, Francis M. Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin. Journal of Medicinal Chemistry. Volume 36. Issue 15. Pages 2228-31. 1993.
产品链接: CAS No. 146464-95-1 ››
DeGraw, Joseph I.; Colwell, William T.; Piper, James R.; Sirotnak, Francis M. Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin. Journal of Medicinal Chemistry. Volume 36. Issue 15. Pages 2228-31. 1993.
产品链接: CAS No. 146464-95-1 ››