Zoliflodacin CAS# 1620458-09-4 唑利氟达星
Zoliflodacin, also known as AZD0914 and ETX0914, is a new spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor with potent in vitro antibacterial activity against key Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus agalactiae), fastidious Gram-negative (Haemophilus influenzae and Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. AZD0914 works via inhibition of DNA biosynthesis and accumulation of double-strand cleavages.
📌 参考资料/链接：
Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)By: Basarab, Gregory S.; et alJournal of Medicinal Chemistry (2015), 58(15), 6264-6282
Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)By: Basarab, Gregory S.; et alJournal of Medicinal Chemistry (2015), 58(15), 6264-6282
📄 详细内容
CAS No. 1620458-09-4 唑利氟达星Zoliflodacin synthetic routes
Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)By: Basarab, Gregory S.; et alJournal of Medicinal Chemistry (2015), 58(15), 6264-6282
产品链接: CAS No. 1620458-09-4 ››
Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)By: Basarab, Gregory S.; et alJournal of Medicinal Chemistry (2015), 58(15), 6264-6282
产品链接: CAS No. 1620458-09-4 ››