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临床前CDMO研发化合物筛选
Afuresertib (GSK2110183)
中文名称:GSK-2110183C无结构图
CAS号:1047644-62-1
分子式: C18H17Cl2FN4OS 分子量: 427.32
产品形式: free base
研发状态: Completed
研发用途: Healthy Volunteer
研究机构: Laekna Limited
研发日期: August 6 2022
研发阶段: Phase 1
Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
Uprosertib (GSK2141795)
中文名称:Uprosertib,GSK2141795抑制剂
CAS号:1047634-65-0
分子式: C18H16Cl2F2N4O2 分子量: 429.25
产品形式: free base
研发状态: Terminated
研发用途: Cervical Cancer
研究机构: Dana-Farber Cancer Institute; Novartis; National Comprehensive Cancer Network
研发日期: Oct-13
研发阶段: Phase 2
Uprosertib (GSK2141795, GSK795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.
Pramipexole
中文名称:普拉克索
CAS号:104632-26-0
分子式: C10H17N3S 分子量: 211.33
产品形式: Free Base
研发状态: Not yet recruiting
研发用途: Anxiety Disorders; Anxiety; Depression; Social Disconnection
研究机构: University of California San Diego; National Institute of Mental Health (NIMH); New York State Psychiatric Institute
研发日期: Feb-24
研发阶段: Phase 2
Pramipexole (SND 919,Mirapexin,Sifrol,Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
Apabetalone (RVX-208)
中文名称:2-(4-(2-羟基乙氧基)-3,5-二甲基苯基)-5,7-二甲氧基喹唑啉-4(3H)-酮
CAS号:1044870-39-4
分子式: C20H22N2O5 分子量: 370.40
产品形式: free base
研发状态: Not yet recruiting
研发用途: Kidney Failure Chronic
研究机构: Resverlogix Corp
研发日期: November 22 2024
研发阶段: Phase 1 : Phase 2
Apabetalone (RVX-208, RVX-000222) is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2.
Ceftriaxone disodium salt hemi (heptahydrate)
中文名称:头孢曲松钠
CAS号:104376-79-6
分子式: C18H16N8O7S3.7/2H2O.2Na 分子量: 661.60
产品形式: disodium salt hemi
研发状态: Recruiting
研发用途: Antibiotic Toxicity; Liver Cirrhosis; Renal Insufficiency; Ceftriaxone Overdose; Ascites Hepatic; Infection Bacterial
研究机构: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Erasmus Medical Center
研发日期: July 10 2023
研发阶段: --
Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic.
Famciclovir
中文名称:泛昔洛韦
CAS号:104227-87-4
分子式: C14H19N5O4 分子量: 321.34
产品形式: free base
研发状态: Unknown status
研发用途: Multiple Sclerosis
研究机构: Queen Mary University of London
研发日期: November 25 2020
研发阶段: Phase 2
Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.
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