CAS: 1047644-62-1; N-((S)-1-Amino-3-(3-Fluorophenyl)Propan-2-yl)-5-Chloro-4-(4-Chloro-1-Methyl-1H-Pyrazol-5-yl)Thiophene-2-Carboxamide

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5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-N-{(1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-[(3-fluorophenyl)methyl]ethyl}-2-thiophenecarboxamide methyl 5-chloro-4-iodo-2-thiophenecarboxylate methyl 5-chloro-4-(1-methylpyrazol-5-yl)-2-thiophenecarboxylate 5-Chlorothiophene-2-carboxylic acidN-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydr°Chloride

📜Tert-Butyl [(1S)-1-(3-Fluorobenzyl)-2-Hydroxyethyl]Carbamate置于盐酸,偶氮二甲酸二异丙酯,N,N-二异丙基乙胺,三苯基膦,Pybrop,肼体系中,用 四氢呋喃,甲醇,二氯甲烷 用作溶剂,化学反应生成Gsk-2110183C无结构图
参考文献:Afuresertib: Protein Kinase B (Pkb) Inhibitor Oncolytic
标题:Afuresertib: Protein Kinase B (Pkb) Inhibitor Oncolytic
摘要:The Phosphatidylinositol 3-Kinase (513K)/akt/mammallan Target Of Raparnycin (Mtor) Signaling Pathway Plays Key Roles In Cellular Proliferation And Survival. Mutations And Alterations In This Signal Transduction Pathway Have Been Described In A Variety Of Solid And Hematopoietic Malignancies,Which May Contribute To Perpetuation Of The Disease In A Number Of Ways. Increasing Interest In Targeting Particular Facets Of This Signaling Cascade Has Led To The Development Of A Number Of Novel Anticancer Agents,Including Afuresertib (Gsk-2770783),An Orally Bioavailable Pan-Inhibitor Of The Rac-Alpha Serine/threonine Protein Kinase,Also Referred To As Protein Kinase B Or Proto-Oncogene C-Akt. The Present Review Summarizes The Preclinical And Pharmacological Aspects Of Afuresertib And Early Clinical Experience.
Doi:10.1358/dof.2014.039.08.2177902