CAS: 104227-87-4; 2-(2-(2-Amino-9H-Purin-9-yl)Ethyl)Propane-1,3-Diyl Diacetate

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CAS号108-24-7 乙酸酐 | CAS号104227-86-3 泛昔洛韦USP相关物质A | CAS号97845-60-8 9-[4-乙酰氧基-3-(乙酰... | CAS号128139-27-5 9-(4-acetoxy-3-... | CAS号225111-66-0 9-[4-acetoxy-3-... | CAS号73-40-5 鸟嘌呤 | CAS号172529-94-1 2-[2-(2-amino-6... | CAS号127047-77-2 2-(乙酰氧基甲基)-4-碘乙酸丁酯 | CAS号452-06-2 2-氨基嘌呤 | CAS号39809-25-1 喷昔洛韦 | CAS号104227-90-9 [4-(2-aminopuri... | CAS号104227-86-3 泛昔洛韦USP相关物质A

鸟苷置于palladium On Activated Charcoal 吡啶,4-二甲氨基吡啶,Sodium Hydroxide,氢气,甲酸铵,三乙胺,甲胺体系中,用 四氢呋喃,N-甲基吡咯烷酮,甲醇,乙醇,二氯甲烷,二甲基亚砜 用作溶剂,20.0~150.0 °C,300.0 Kpa 条件下,反应 52.25H,反应生成泛昔洛韦
参考文献:Regioselective Functionalization Of Guanine: Simple And Practical Synthesis Of 7-And 9-Alkylated Guanines Starting From Guanosine
标题:Regioselective Functionalization Of Guanine: Simple And Practical Synthesis Of 7-And 9-Alkylated Guanines Starting From Guanosine
摘要:N-2-Acetyl-9-和/或-7-苄基化鸟嘌呤8和12与选定的烷基化试剂在120oc的1-甲基-2-吡咯烷酮中反应,得到鸟碱盐9和13.随后,这些盐通过相转移氢化反应,分别以高度选择性的方式转化为n7-和n9-同分异构体10和14.此外,还建立了一种便利的去氧化反应,通过相应的o6-芳烃磺酸酯,将这两种衍生物转化为2-氨基嘌呤的潜在前药.
Doi:10.1055/s-2004-829174

专利信息

专利号:WO-2023118363-A1
优先权日:2021-12-22
标题:Method for the synthesis of a carbonyl-functionalised adduct
发明人：GODEHARD SIMON P; PELZER ALEXANDER
权利人:BRAIN Biotech AG
摘要:The invention relates to a method for the synthesis of a carbonyl-functionalised adduct.

专利号:US-6818633-B2
优先权日:2001-06-29
标题:Antiviral compounds and methods for synthesis and therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

专利号:US-7189849-B2
优先权日:1997-02-10
标 题:Synthesis of acyclic nucleoside derivatives
发明人：LEANNA M ROBERT; RASMUSSEN MICHAEL; HANNICK STEVEN M; TIEN JIEN-HEH J; LUKIN KIRILL A; TIAN ZHENPING; CHANG SOU-JEN; CURTY CYNTHIA B; NARAYANAN BIKSHANDARKOIL A; BELLETTINI JOHN; SHELAT BHADRA; SPITZ TIFFANY
权利人:MEDIVIR AB
摘要:Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.

专利号:US-2015376219-A1
优先权日:2014-06-30
标题 :Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods
发明人：ZHONG MINGHONG
权利人:ZHONG MINGHONG
摘要:A process of regiospecific synthesis of N-9 purine nucleoside analogs in either solution or solid phase synthesis is described. The introduction of the sugar moiety or its analogue on to a 6-heteroarylium purine or its mesomeric betaine so that formation of only the N-9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific introduction of the sugar moiety allows the synthesis of purine nucleoside analogs in high yields without formation of the N-7-positional regioisomers, while the 6-heteroaryliums are leaving groups facilitated for nucleophilic displacement. Solid supported 6-heterarylium purine bases can be used for purine based library synthesis and synthesis of nucleotide monophosphates and polyphosphates. Processes for providing novel 6-heteroarylium purines and their corresponding mesomeric betaines for the regiospecific synthesis of N-9 purine nucleoside analogs and nucleotides are described.

专利号:US-7855285-B2
优先权日:2005-06-14
标 题:Methods for selective N-9 glycosylation of purines
发明人：ROBINS MORRIS J; ZHONG MINGHONG
权利人:UNIV BRIGHAM YOUNG
摘要:A process for providing regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs is described. The introduction of the sugar moiety on to 6-(azolyl)-substituted purine bases is performed so that highly stereoselective formation of the β anomers of only the 9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs, and in particular 2′-deoxy, 3′-deoxy, 2′-deoxy-2′-halo-arabino and 2′,3′-dideoxy-2′-halo-threo purine nucleoside analogs, in high yields without formation of the 7-positional regioisomers. Processes for providing novel 6-(azolyl)purines for the regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs are described. The compounds are drugs or intermediates to drugs.

专利号:US-2024082118-A1
优先权日:2021-05-19
标 题:Topical compositions and methods of preparing the same
发明人：ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION
权利人:LANDA LABS 2012 LTD
摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.