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临床前CDMO研发化合物筛选
Tamoxifen (ICI 46474)
中文名称: 他莫昔芬
CAS号:10540-29-1
分子式: C26H29NO 分子量: 371.51
产品形式: Free Base
研发状态: Not yet recruiting
研发用途: Metastatic Breast Cancer; Tumor; Muscle Neoplasms; Chronic Pain
研究机构: DR. DIANE CHISESI NFS. MD. PHD.; IRB; Paradyne Networks A Foundation
研发日期: Jul-24
研发阶段: --
Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) is a selective estrogen receptor modulator (SERM). Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.
Dolutegravir (GSK1349572)
中文名称:度鲁特韦
CAS号:1051375-16-6
分子式: C20H19F2N3O5 分子量: 419.38
产品形式: free base
研发状态: Not yet recruiting
研发用途: Pediatric HIV Infection; Latent Tuberculosis
研究机构: Brigham and Women''s Hospital; APIN Public Health Initiatives; University of Cape Town
研发日期: May-24
研发阶段: Phase 1
Dolutegravir (GSK1349572,S/GSK1349572,Tivicay) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM in a cell-free assay, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
Cabotegravir (GSK1265744)
中文名称:卡替拉韦
CAS号:1051375-10-0
分子式: C19H17F2N3O5 分子量: 405.35
产品形式: free base
研发状态: Recruiting
研发用途: Oral Pre-exposure Prophylaxis (PrEP); Long-acting Injectable Cabotegravir for PrEP
研究机构: Georgetown University; AIDS Vaccine Advocacy Coalition; Centers for Disease Control and Prevention; Center for the Development of People; Cooper/Smith; Elizabeth Glaser Pediatric AIDS Foundation; Family Health Services; Healthqual; Johns Hopkins Research Project Malawi; Johns Hopkins Bloomberg School of Public Health; Kamuzu University of Health Sciences; Blantyre District Health Office Malawi; Lilongwe District Health Office Malawi; Lighthouse Trust; Ministry of Health Malawi; National AIDS Commission Malawi; Pakachere Institute of Health and Development Communication; Partners in Hope; Population Services International; University of North Carolina; United States Agency for International Development (USAID); United States President''s Emergency Plan for AIDS Relief; Quantitative Engineering Design; Clinton Health Access Initiative-Malawi
研发日期: March 26 2024
研发阶段: --
Cabotegravir (GSK744, GSK1265744, S/GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2.
Balixafortide (POL6326)
中文名称:拮抗剂多肽BALIXAFORTIDE
CAS号:1051366-32-5
分子式: C84H118N24O21S2 分子量: 1864.11
产品形式: Free base
研发状态: Withdrawn
研发用途: Advanced Breast Cancer
研究机构: MedSIR
研发日期: March 16 2022
研发阶段: Phase 1 : Phase 2
Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.
Finerenone
中文名称:(4S)-4-(4-氰基-2-甲氧基苯基)-5-乙氧基-1,4-二氢-2,8-二甲基-1,6-萘啶-3-甲酰胺(非奈利酮杂质)
CAS号:1050477-31-0
分子式: C21H22N4O3 分子量: 378.42
产品形式: Free base
研发状态: Not yet recruiting
研发用途: Asthma; Asthma in Children; Allergy; Rhinitis Allergic; Atopic Dermatitis; Allergen Immunotherapy
研究机构: Tampere University; Professor Lauri Lehtimäki; Professor Mika Mäkelä; Professor Sanna Toppila-Salmi; Professor Ilkka Junttila
研发日期: Oct-24
研发阶段: --
Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.
Tacrolimus (FK506)
中文名称:他克莫司
CAS号:104987-11-3
分子式: C44H69NO12 分子量: 804.02
产品形式: free base
研发状态: Not yet recruiting
研发用途: Hyperglycemia; Renal Transplant Complication Primary Non-Function; Diabetes
研究机构: Rigshospitalet Denmark; Aarhus University Hospital; Odense University Hospital
研发日期: April 1 2024
研发阶段: Phase 4
Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.
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