临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 486-66-8

Daidzein

中文名称:大豆苷元
CAS号:486-66-8
分子式: C15H10O4 分子量: 254.24
产品形式: free base
研发状态: Completed
研发用途: Healthy
研究机构: Chalmers University of Technology
研发日期: September 27 2021
研发阶段: Not Applicable
Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. Daidzein is a soy isoflavone, which acts as a PPAR activator.

CAS: 486-56-6

S-(-)-Cotinine

中文名称:吡啶吡咯酮
CAS号:486-56-6
分子式: C10H12N2O 分子量: 176.22
产品形式: free base
研发状态: Not yet recruiting
研发用途: Shisha
研究机构: University of Minnesota
研发日期: February 1 2025
研发阶段: Not Applicable
S-(-)-Cotinine, a constituent of tobacco products and the major metabolite of nicotine, stimulates nicotinic receptors to evoke the release of DA in a calcium-dependent manner from superfused rat striatal slices.,

CAS: 486460-32-6

Sitagliptin

中文名称:西他列汀
CAS号:486460-32-6
分子式: C16H15F6N5O 分子量: 407.31
产品形式: free base
研发状态: Not yet recruiting
研发用途: Type 1 Diabetes
研究机构: University of Milan
研发日期: Jul-23
研发阶段: Phase 2 : Phase 3
Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.

CAS: 485-35-8

Cytisine

中文名称: 金雀花碱
CAS号:485-35-8
分子式: C11H14N2O 分子量: 190.24
产品形式: free base
研发状态: Recruiting
研发用途: Nicotine Addiction
研究机构: Loma Linda University; Pfizer; Mongolian National University of Medical Sciences
研发日期: January 27 2022
研发阶段: Phase 3
Cytisine (Baphitoxine, Sophorine) is a nicotinic acetylcholine receptor agonist.

CAS: 482-89-3

Indigo

中文名称: 靛蓝
CAS号:482-89-3
分子式: C16H10N2O2 分子量: 262.26
产品形式: free base
研发状态: Unknown status
研发用途: Lower Limb Ischemia
研究机构: Lancashire Care NHS Foundation Trust; St. Franziskus Hospital
研发日期: November 1 2017
研发阶段: Not Applicable
Indigo (Indigotin) dye is an organic compound with a distinctive blue color. It is extracted from the leaves of certain plants or synthetic.

CAS: 480-41-1

Naringenin

中文名称:柚皮素; 4',5,7-三羟基黄烷酮
CAS号:480-41-1
分子式: C15H12O5 分子量: 272.25
产品形式: free base
研发状态: Completed
研发用途: Healthy
研究机构: Chalmers University of Technology
研发日期: September 27 2021
研发阶段: Not Applicable
Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.