CAS: 486-56-6; (S)-1-Methyl-5-(Pyridin-3-yl)Pyrrolidin-2-One

上下游产品

CAS号201230-82-2 carbon monoxide | CAS号3471-04-3 2-Pyrrolidinone... | CAS号54-11-5 L-尼古丁 | CAS号74093-56-4 3,3-Dibromo Cotinine | CAS号487-19-4 二烯烟碱 | CAS号34834-67-8 3'R,5'S)-3'-羟基可替宁 | CAS号37096-14-3 顺式3'-羟基可替宁 | CAS号36508-80-2 1-Methyl-5-(1-O... | CAS号3000-74-6 3-Pyridinebutan... | CAS号54-11-5 L-尼古丁 | CAS号71014-67-0 S-(-)-尼古丁-δ1'-(...

📜烟碱置于glucose-6-Phosphate Dehydrogenase,Glucose-6-Phosphate,Cyp2A6.1,Wild-Type,烟酰胺腺嘌呤双核苷酸磷酸盐,Magnesium Chloride体系中,用 Aq. Buffer 作为反应溶剂,化学反应生成 吡啶吡咯酮
参考文献:Effect Of Cyp2A6 Genetic Polymorphism On The Metabolic Conversion Of Tegafur To 5-Fluorouracil And Its Enantioselectivity
标题:Effect Of Cyp2A6 Genetic Polymorphism On The Metabolic Conversion Of Tegafur To 5-Fluorouracil And Its Enantioselectivity
摘要:替加氟(Ft)是一种5-氟尿嘧啶的前体药物,属于手性分子,是r和s两种对映体的消旋混合物,Cyp2A6在ft的人源肝微粒体的对映体选择性代谢中发挥重要作用(R-Ft>S-Ft).本研究检测了由表达野生型cyp2A6及其编码亚型(Cyp2A6*7,*8,*10和*11)的sf9细胞制备的微粒体对ft的对映体选择性代谢影响.cyp2A6*7,*8,*10和*11是亚洲人群中的高频亚型.同时检测了这些亚型对cyp2A6的探针底物香豆素和尼古丁的代谢水平.酶动力学结果显示,Cyp2A6.7(I471T)和cyp2A6.10(I471T和r485L)对ft的r和s对映体的最大反应速率均明显低于野生型酶(Cyp2A6.1)及其他亚型,而大多数亚型对ft的r和s对映体的米氏常数均高于cyp2A6.1.对ft的r和s对映体的最大反应速率与米氏常数之比的比值在各亚型间没有明显差异,表明野生型cyp2A6及其亚型对ft的对映体选择性类似,对香豆素7-羟化酶及尼古丁c-氧化酶活性的最大反应速率的影响与对ft的对映体影响有类似趋势,表明cyp2A6亚型中的氨基酸突变导致了酶与底物亲和力的下降,且仅cyp2A6.7和cyp2A6.10的最大反应速率下降.cyp2A6.1及其亚型对ft的r和s对映体的最大反应速率与米氏常数之比的比值相同,表明cyp2A6各亚型中的氨基酸突变对ft的对映体选择性代谢没有影响.
DOI:10.1124/dmd.114.058008

专利信息

专利号:US-9440948-B2
优先权日:2010-09-03
标题:Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use
发明人：KEM WILLIAM READE; SOTI FERENC; ROUCHAUD ANNE; XING HONG; LINDSTROM JON; ANDRUD KRISTIN MARIE
权利人:KEM WILLIAM READE; SOTI FERENC; ROUCHAUD ANNE; XING HONG; LINDSTROM JON; ANDRUD KRISTIN MARIE; UNIV FLORIDA; UNIV PENNSYLVANIA
摘要:Embodiments of the present disclosure provide for compounds such as those shown in FIG. 1.1 (compounds A, B, C, and D), 2′substituted nicotine compounds, azetidine compounds, ether linked nicotine compounds (FIG. 1.2 , compounds E, F, G, and H), methods of synthesis of the compounds, methods of treatment of a condition using compounds A, B, C, D, 2′substituted nicotine compounds, azetidine compounds, or ether linked nicotine compounds, methods of selectively stimulating alpha7 nAChR and/or alpha4beta2 receptors, and the like.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:US-11078093-B2
优先权日:2017-06-30
标 题 :Surfactant-assisted synthesis of surface-functionalized nanoparticle-polymer electrospun composites
发明人：CWIERTNY DAVID; MYUNG NOSANG; PETER KATHERINE T; PARKIN GENE FRANCIS
权利人:UNIV CALIFORNIA; UNIV IOWA RES FOUND
摘要:A method is disclosed for synthesizing nanofilters for water treatment. The method includes: dispersing an active binding agent in an organic solvent solution to create a suspension of the active binding agent and the solution of the solvent; dissolving an organic polymer resin and an anionic surfactant in the suspension of the active binding agent and the solvent solution to create a sol gel; and electrospinning the sol gel to form electrospun nanofiber composites with embedded, surface-active nanoparticles.

专利号:WO-2024105569-A1
优先权日:2022-11-15
标题 :System for treating water, generating hydrogen and generating synthesis gas
发明人：MACHUCA MARTà NEZ FIDERMAN; LARA RAMOS JOSÉ ANTONIO; DIAZ ANGULO JENNYFER
权利人:UNIV DEL VALLE
摘要:The present invention relates to a system for treating water and wastewater, which is based on an electrochemical reactor formed by two electrodes (anode and cathode) that are irradiated by UV radiation lamps. The system can perform processes of electrochemical adsorption, photocatalysis and photolysis simultaneously, thereby generating hydrogen and synthesis gas from water treatment. In the system, an adsorbent material held by a mesh support is adhered to the electrodes. The system also comprises an ion-exchange membrane, which separates two pieces that form a case, the anodes and cathodes being disposed inside each piece. To remove the gases in the fluid stream that are entering the electrochemical reactor, the system includes a gas purge valve device located at the treatment entry.

专利号:US-2019002309-A1
优先权日:2017-06-30
标 题 :Surfactant-assisted synthesis of surface-functionalized nanoparticle-polymer electrospun composites

专利号:US-7749985-B2
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
发明人：GALLOP MARK A; XU FENG; PHAN THU; DILIP USHA; PENG GE
权利人:XENOPORT INC
摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.