CAS: 486-66-8; 7-Hydroxy-3-(4-Hydroxyphenyl)-4H-Chromen-4-One

上下游产品

CAS号485-72-3 芒柄花黄素 | CAS号2491-38-5 α-溴代对羟基苯乙酮 | CAS号95-01-2 2,4-二羟基苯甲醛 | CAS号56401-06-0 7-苄基黄豆苷元 | CAS号17720-60-4 1-(2,4-二羟基苯基)-2... | CAS号122-51-0 原甲酸三乙酯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号552-66-9 大豆苷 | CAS号156-38-7 对羟基苯乙酸 | CAS号17817-31-1 6,7,4'-三羟基异黄酮 | CAS号40957-83-3 黄豆黄素 | CAS号485-63-2 7,3',4'-三羟基异黄酮(... | CAS号485-72-3 芒柄花黄素 | CAS号1157-39-7 大豆苷元甲醚 | CAS号486-63-5 异刺芒柄花素 | CAS号21255-69-6 O-Desmethylango... | CAS号291759-05-2 黄豆苷-d6 | CAS号552-66-9 大豆苷 | CAS号602329-51-1 4'-O-己酰基黄豆苷元

雌马酚 反应生成 大豆甙元
参考文献:Fermented Soya Based Mixture Comprising Isoflavones-Aglicones,Equol And Lunasil,Process For The Preparation And Uses Thereof In Food,Medical And Cosmetic Fields
标题:Fermented Soya Based Mixture Comprising Isoflavones-Aglicones,Equol And Lunasil,Process For The Preparation And Uses Thereof In Food,Medical And Cosmetic Fields
摘要:本发明涉及一种混合物,该混合物包括异黄酮-缩醛,例如大豆异黄酮,甘黄酮和异甘黄酮,以及伊库尔和卢纳辛,该混合物基于使用从食品基质中分离出的乳酸菌发酵的大豆,并且使用该混合物用于保护皮肤和类似的人体肠道细胞,特别是预防炎症状态和保护屏障功能以及治疗脱发.

专利信息

专利号:WO-2012004653-A8
优先权日:2010-07-07
标 题:Method for inhibition of nf-kb gene expression
发明人：BHATTACHARYA SUSHMITA; DASGUPTA SUMAN; BARMA POMY; BISWAS ANINDITA; PAL BIKASH CHANDRA; BHATTACHARYA SHELLEY; BHATTACHARYA SAMIR; BORDOLOI MANOBJYOTI; BARUA NABIN CHANDRA; RAO PARUCHURI GANGADHAR
权利人:COUNCIL SCIENT IND RES; VISVA BHARATI SCHOOL OF LIFE SCIENCES; BHATTACHARYA SUSHMITA; DASGUPTA SUMAN; BARMA POMY; BISWAS ANINDITA; PAL BIKASH CHANDRA; BHATTACHARYA SHELLEY; BHATTACHARYA SAMIR; BORDOLOI MANOBJYOTI; BARUA NABIN CHANDRA; RAO PARUCHURI GANGADHAR
摘要:The present invention discloses a method of inhibition of synthesis of NF- kB by inhibiting its gene expression using isoflavones Daidzein and Daidzin. Daidzein, a non toxic dietary supplement isoflavone of the structure (1) and 7-O-ϵ-glucopyranosyl daidzein of the structure (2) are novel inhibitors of NF- kB which blocks the synthesis of NF- kB by inhibiting its gene expression and have no toxic effect. Both daidzein of the structure (1) and daidzin of the structure (2) ameliorate palmitate induced overexpression of NF- kB in skeletal muscle cells by eliminating the inhibition of NF- kB on insulin stimulated glucose uptake. Daidzein inhibits NF- kB expression in prostate and breast cancer cells that increased mortality of these cancer cells. Daidzin of the structure (2) has very good bioavailibility over daidzein of structure (1). Daidzein of the structure (1) is not absorbed when orally fed to mice as it is eliminated from the gut through glucuronidation process catalyzed by UGT1. Daidzin of the structure (2) is glucosylated daidzein and is protected from UGT1 mediated degradation and is hydrolysed to daidzein which is absorbed and remains for more than 4 hours in blood and is expected to be distributed to different tissues and organs. Daidzein of the structure (1) and daidzin of the structure (2) reduce palmitate stimulated increased synthesis of NF- kB significantly. Daidzein inhibits formation of NF- kB -DNA complex stimulated by palmitate and both daidzein and daidzin inhibited NF- kB expression which leads to reduction of its DNA binding. Daidzein of the structure(1) was obtained from soy leaves through chromatography and both natural and synthetic daidzein and daidzin have same biological activities.

专利号:US-2008146656-A1
优先权日:2005-06-01
标题:Use of a steroid sulphatase inhibitor for inhibiting the synthesis of androstenedione and/or testosterone
发明人：REED MICHAEL JOHN; PUROHIT ATUL; WOO LOK WAI LAWRENCE; POTTER BARRY VICTOR LLOYD
权利人:REED MICHAEL JOHN; PUROHIT ATUL; WOO LOK WAI LAWRENCE; POTTER BARRY VICTOR LLOYD
摘要:There is provided use of a compound capable of inhibiting a steroid sulphatase enzyme (E.C.3.1.6.2) in the manufacture of a medicament for inhibiting in vivo synthesis of at least one of androstenedione and testosterone, which may be useful for the treatment of hirsutism, excess sebum production, benign breast disease, benign ovarian disease, polycystic ovarian disease and female infertility among others.

专利号:WO-2025081225-A1
优先权日:2023-10-17
标 题 :Synthesis of polyphenols
发明人：TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT
权利人:Delica Therapeutics Pty Ltd
摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.

专利号:US-2012003164-A1
优先权日:1998-12-30
标题 :Cosmetic or dermatological composition containing an active agent which stimulates synthesis of the protein hsp 32 in the skin
发明人：NIZARD CARINE; MOREAU MARIELLE; BONTE FREDERIC
权利人:NIZARD CARINE; MOREAU MARIELLE; BONTE FREDERIC; DIOR CHRISTIAN PARFUMS
摘要:A dermatological or cosmetological composition for an external topical administration, included together with pharmaceutically and/or cosmetologically acceptable excipients: at least one UVA-stabilizing and/or UVB-stabilizing screening agent, at least one compound capable of activating the endogenous synthesis of Heat Shock Protein (HSP) 32 or a functional peptide fragment of such a protein, and forskolin or any extract containing it.

专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.