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临床前CDMO研发化合物筛选
Cenicriviroc (TAK-652)
CAS号:497223-25-3
分子式: C41H52N4O4S 分子量: 696.94
产品形式: free base
研发状态: Not yet recruiting
研发用途: End Stage Renal Disease
研究机构: Xeltis
研发日期: Jul-24
研发阶段: Not Applicable
Cenicriviroc (CVC, TAK-652, TBR-652) is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity.
Eltrombopag (SB497115) Olamine
中文名称:艾曲波帕乙醇胺
CAS号:496775-62-3
分子式: C29H36N6O6 分子量: 564.63
产品形式: diolamine
研发状态: Terminated
研发用途: Adult Acute Basophilic Leukemia; Adult Acute Eosinophilic Leukemia; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Myeloid Leukemia
研究机构: Roswell Park Cancer Institute; GlaxoSmithKline
研发日期: May-12
研发阶段: Phase 1
Eltrombopag Olamine (SB-497115-GR, Revolade, Promacta,Promacta Olamine) is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR).
Eltrombopag
中文名称:伊屈泼帕
CAS号:496775-61-2
分子式: C25H22N4O4 分子量: 442.47
产品形式: Free Base
研发状态: Recruiting
研发用途: Lymphoma; Peripheral Blood Stem Cell Transplantation
研究机构: National Taiwan University Hospital; Novartis
研发日期: August 15 2023
研发阶段: Phase 2
Eltrombopag (SB-497115), a member of the biarylhydrazone class, is a nonpeptide agonist of the thrombopoietin receptor (TpoR), used to treat chronic hepatitis C-associated thrombocytopenia and chronic immune (idiopathic) thrombocytopenia (ITP).
Hippuric acid
中文名称:马尿酸
CAS号:495-69-2
分子式: C9H9NO3 分子量: 179.17
产品形式: free base
研发状态: Recruiting
研发用途: Renal Insufficiency Chronic; Kidney Failure Chronic; Chronic Kidney Diseases
研究机构: UMC Utrecht; European Commission Horizon 2020; Dutch Kidney Foundation; Health Holland; Nanodialysis Ltd; Università degli studi di Modena e Reggio Emilia (UNIMORE); Servicio Madrileno De Salud (SERMAS); PPI Healthcare Consulting Ltd
研发日期: January 22 2024
研发阶段: Not Applicable
Hippuric Acid (2-Benzamidoacetic acid, Benzoylglycine) is an acyl glycine produced by the conjugation of benzoic acid and glycine, found as a normal component in urine as a metabolite of aromatic compounds from food.
Fenofibrate (NSC-281319)
中文名称:非诺贝特
CAS号:49562-28-9
分子式: C20H21ClO4 分子量: 360.83
产品形式: free base
研发状态: Recruiting
研发用途: Liver Transplant
研究机构: Mayo Clinic
研发日期: August 17 2022
研发阶段: Phase 2
Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.
Saroglitazar
中文名称:萨格列扎
CAS号:495399-09-2
分子式: C25H29NO4S 分子量: 439.57
产品形式: Free Base
研发状态: Recruiting
研发用途: Nonalcoholic Steatohepatitis
研究机构: Zydus Therapeutics Inc.
研发日期: September 26 2022
研发阶段: Phase 2
Saroglitazar (Lipaglyn, ZYH1) is an agonist of peroxisome proliferator-activated receptor (PPAR) with EC50 of 0.65 pM and 3 nM for hPPARα and hPPARγ in HepG2 cells, respectively.
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