CAS: 49562-28-9; Isopropyl 2-(4-(4-Chlorobenzoyl)Phenoxy)-2-Methylpropanoate

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CAS号42017-89-0 非诺贝特酸 | CAS号67-63-0 异丙醇 | CAS号75-26-3 2-溴丙烷 | CAS号42019-78-3 4-氯-4'-羟基二苯甲酮 | CAS号1375008-18-6 isopropyl 2-(4-... | CAS号1679-18-1 4-氯苯硼酸 | CAS号82102-37-2 9-Methylfluoren... | CAS号51368-55-9 2-溴代异丁酸异丙酯 | CAS号122-01-0 4-氯苯甲酰氯 | CAS号100-66-3 苯甲醚 | CAS号42017-89-0 非诺贝特酸 | CAS号61001-99-8 propan-2-yl 2-[...

Isopropyl 2-(4-(1-(4-Chlorophenyl)Vinyl)Phenoxy)-2-Methylpropanoate置于n-羟基丁二酰亚胺,Graphitic Carbon Nitride,氧气体系中,用 乙腈 作为反应溶剂,以75%的收率获得产物非诺贝特
参考文献:一种无金属的非均相光催化剂,用于通过收集直接太阳能选择性氧化裂解芳基烯烃中的cc键
标题:一种无金属的非均相光催化剂,用于通过收集直接太阳能选择性氧化裂解芳基烯烃中的cc键
摘要:C C键的选择性裂解对于合成含羰基的精细化学品和药物非常重要.新型方法,例如臭氧分解反应,Lemieux-Johnson氧化反应等.已经存在.与此平行,还发现了使用均相催化剂的催化方法.考虑到非均相催化剂的各种优点,例如可循环性和稳定性,已将几种基于过渡金属的非均相催化剂用于该反应.但是,制药行业更喜欢使用不含金属的催化剂(尤其是不含过渡金属的催化剂),以避免最终产品中进一步浸出.对于有机化学家和制药行业来说,这无疑是一个巨大的挑战!为了使之可行,已经开发了一种温和而有效的方案,使用聚合碳氮化物(pcn)作为无金属的非均相光催化剂,将各种烯烃转化为相应的羰基.后来,该催化剂已被用于使用直接太阳能的克级合成药物中.详细的机械研究揭示了氧气,催化剂和光源的实际作用.
DOI:10.1039/d0Gc01187H

专利信息

专利号:WO-2023102600-A1
优先权日:2021-12-06
标题:Synthesis of amphiphilic block copolymers and polymeric nanofibers produced therefrom
发明人：ZETTERLUND PER B; ISHIZUKA FUMI; KIM HYUN JIN; CHATANI SHUNSUKE; NIINO HIROSHI
权利人:NEWSOUTH INNOVATIONS PTY LTD
摘要:The present disclosure relates to the field of synthesis of block copolymers, and polymeric nanofibers having a core-shell morphology produced therefrom. The present disclosure relates to the field of synthesis of block copolymers where one block is more hydrophobic than the other block and is a different composition. The disclosure also relates to uses of these polymeric nanofibers in various applications, such as reinforcing a polymeric matrix and for coatings applications.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2009053804-A1
优先权日:2007-07-27
标题:Methods of reducing intracellular fats from mammalian cells
发明人：RUIZ JOSEPH CHARLES
权利人:VESTA THERAPEUTICS INC
摘要:The present invention provides methods of reducing or clearing fat from mammalian cells. The method comprises culturing the cells in an environment that facilitates: 1) reduction of de novo fatty acid synthesis, 2) activation or synthesis of fatty acid oxidizing enzymes, and/or 3) export of lipids out of the cells. Cells substantially free of fatty acid are also provided in this invention.

专利号:US-8846916-B2
优先权日:2009-05-11
标题:Sitagliptin synthesis
发明人：GORE VINAYAK GOVIND; GADAKAR MAHESHKUMAR; BHOSLE PRIYANKA; SHINDE SURESH
权利人:GORE VINAYAK GOVIND; GADAKAR MAHESHKUMAR; BHOSLE PRIYANKA; SHINDE SURESH; GENERICS UK LTD
摘要:The present invention relates to novel processes for the preparation of enantiomerically enriched β-amino acid derivatives such as β-amino esters useful for the synthesis of enantiomerically enriched biologically active molecules such as sitagliptin. The key step involves the resolution of the racemate with mandelic acid.

专利号:US-12269811-B2
优先权日:2017-06-30
标 题:Synthesis of omecamtiv mecarbil
发明人：CAILLE SEBASTIEN; QUASDORF KYLE; ROOSEN PHILIPP C; SHI XIANQING; COSBIE ANDREW; WANG FANG; WU ZUFAN; NEERGUNDA ARCHANA; QUAN BIN PETER; GUAN LIANXIU
权利人:AMGEN INC
摘要:Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (1)