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临床前CDMO研发化合物筛选
Cortisone acetate
中文名称:醋酸可的松
CAS号:50-04-4
分子式: C23H30O6 分子量: 402.48
产品形式: free base
研发状态: Recruiting
研发用途: Alzheimer Disease; Dementia
研究机构: University of Miami; Shipley Foundation; Dreem
研发日期: March 1 2023
研发阶段: Not Applicable
Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
Rilpivirine
中文名称:利匹韦林
CAS号:500287-72-9
分子式: C22H18N6 分子量: 366.42
产品形式: free base
研发状态: Recruiting
研发用途: HIV-1-infection
研究机构: Gilead Sciences
研发日期: December 13 2023
研发阶段: Phase 4
Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.
Dexamethasone (MK-125)
中文名称:地塞米松
CAS号:50-02-2
分子式: C22H29FO5 分子量: 392.46
产品形式: free base
研发状态: Not yet recruiting
研发用途: Relapsed and/or Refractory Multiple Myeloma
研究机构: Adriana Rossi; Icahn School of Medicine at Mount Sinai
研发日期: June 3 2024
研发阶段: Phase 1 : Phase 2
Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.
Selisistat (EX 527)
中文名称:6-氯-2,3,4,9-四氢-1H-咔唑-1-羧酰胺
CAS号:49843-98-3
分子式: C13H13ClN2O 分子量: 248.71
产品形式: free base
研发状态: Completed
研发用途: Huntington''s Disease
研究机构: Siena Biotech S.p.A.
研发日期: Nov-11
研发阶段: Phase 1
Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.
AEE788 (NVP-AEE788)
中文名称:6-[4-[(4-乙基-1-哌嗪)甲基]苯基]-N-[(1R)-1-苯基乙基]-7H-吡咯并[2,3-D]嘧啶-4-胺
CAS号:497839-62-0
分子式: C27H32N6 分子量: 440.58
产品形式: free base
研发状态: Completed
研发用途: Brain and Central Nervous System Tumors
研究机构: Novartis Pharmaceuticals; Novartis
研发日期: Oct-03
研发阶段: Phase 1 : Phase 2
AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.
Stiripentol
中文名称: 司替戊醇
CAS号:49763-96-4
分子式: C14H18O3 分子量: 234.29
产品形式: Dioxolane
研发状态: Recruiting
研发用途: Chronic Renal Insufficiency
研究机构: Biocodex
研发日期: July 24 2023
研发阶段: Phase 1
Stiripentol (BCX2600) is a third-generation anti-epileptic drug that enhances GABAergic neurotransmission. It is an inhibitor of cytochrome P450.
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