CAS: 497839-62-0; (R)-6-(4-((4-Ethylpiperazin-1-yl)Methyl)Phenyl)-N-(1-Phenylethyl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine

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CAS号5308-25-8 N-乙基哌嗪

📜在 Lithium Aluminium Tetrahydride,Palladium On Activated Charcoal,氢气,三乙胺,N,N'-羰基二咪唑体系中,用 四氢呋喃,乙醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 4.0H,反应生成 6-[4-[(4-乙基-1-哌嗪)甲基]苯基]-N-[(1R)-1-苯基乙基]-7H-吡咯并[2,3-D]嘧啶-4-胺
参考文献:多置換7−デアザプリン誘導体合成のための2,6−ジクロロ−8−ヨード−7−デアザプリン
标题:多置換7−デアザプリン誘導体合成のための2,6−ジクロロ−8−ヨード−7−デアザプリン
摘要:多置換7-デアザプリン誘導体的合成一直以来,根据置换基的种类和位置,采用各种不同的合成途径.因此,想要合成多样化的衍生物需要大量的时间和精力.解决方法是使用下式(1)所示的2,6-二氯-8-碘-7-デアザプリン作为多置換7-デアザプリン衍生物合成的关键中间体.可以按照8位,6位和2位的顺序引入所需的置换基,因此对于合成目标多置換7-デアザプリン衍生物是有用的中间体.[选择图]无

专利信息

专利号:US-10772971-B2
优先权日:2017-06-22
标 题:Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
发明人：GURIJALA VENU REDDY; BOLLU SATYANARAYAN REDDY; LEBLANC JACQUES; LOWINGER TIMOTHY B; MCGILLICUDDY DENNIS; YIN MAO; YURKOVETSKIY ALEKSANDR V
权利人:MERSANA THERAPEUTICS INC; MERSANA THERPEUTICS INC
摘要:The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.

专利号:US-2024400576-A1
优先权日:2021-09-03
标 题:Nitrogen-containing derivatives of salinomycin, synthesis and uses thereof
发明人：RODRIGUEZ RAPHAËL; CZERWONKA DOMINIKA; ANTOSZCZAK MICHAL; HUCZYNSKI ADAM
权利人:CENTRE NAT RECH SCIENT; INST CURIE; INST NAT SANTE RECH MED; ADAM MICKIEWICZ UNIV
摘要:The present invention relates to nitrogen-containing derivatives of salinomycin having the formula (I), as well as pharmaceutically acceptable salt thereof, and synthesis and uses thereof, in particular for the treatment and/or prevention of cancer including for preventing cancer metastasis and/or for preventing cancer recurrence and/or for decreasing resistance to a chemotherapy in a subject.

专利号:US-2025250280-A1
优先权日:2021-09-03
标 题 :Nitrogen-containing derivatives of narasin, synthesis and uses thereof
发明人：RODRIGUEZ RAPHAËL; CAÑEQUE TATIANA; MÃœLLER SEBASTIAN; ANTOSZCZAK MICHAL
权利人:CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; INST CURIE
摘要:The present invention relates to nitrogen-containing derivatives of narasin having the formula (I), as well as synthesis and uses thereof, in particular for the treatment and/or prevention of cancer. Also disclosed are medicaments including the nitrogen-containing derivatives of narasin, which include medicaments for preventing cancer metastasis and/or for preventing cancer recurrence and/or for decreasing resistance to a chemotherapy in a subject.

专利号:US-12054512-B2
优先权日:2017-11-10
标 题 :Sting modulator compounds, and methods of making and using
发明人：VYSKOCIL STEPAN; CIAVARRI JEFFREY; CULLIS COURTNEY; ENGLAND DYLAN BRADLEY; GOULD ALEXANDRA E; GREENSPAN PAUL; HU YONGBO; LANGSTON STEVEN; LI GANG; MIZUTANI HIROTAKE; OKANIWA MASANORI
权利人:TAKEDA PHARMACEUTICALS CO
摘要:The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases.The present disclosure relates to a compound represented by the Formula (I):wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.

专利号:US-11406709-B2
优先权日:2014-09-15
标 题 :Therapeutic and research application of PDCL3
发明人：RAHIMI NADER
权利人:UNIV BOSTON
摘要:Described herein are novel compositions comprising, for example, PDCL3 polypeptides having VEGFR-2 inhibitory activity, inhibitory PDCL3 antibodies and PDCL3-binding fragments thereof, or PDCL3 inhibitory nucleic acid molecules, and methods of their use in anti-angiogenesis and anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, as well as the treatment of those vascular diseases where pathological angiogenesis plays a role, such as in carotid artery disease, macular degeneration, and plaque neovascularization. Also described herein are novel compositions comprising engineered PDCL3 polypeptides having enhanced chaperone activity, recombinant cells comprising such engineered PDCL3 polypeptides having enhanced chaperone activity, and methods thereof for therapeutic protein production and in vitro protein synthesis.

专利号:US-10272065-B2
优先权日:2013-01-14
标题 :Gem-difluorinated C-glycoside compounds as anti-cancer agents
发明人：SLILATY STEVE N
权利人:ADVANOMICS CORP; BENOIT & COTE
摘要:The present document describes a synthesis of a class of gem-difluorinated C-glycoside compounds derived from podophyllotoxin, which may be used, but not exclusively, in oncology for the treatment of cancer. More particularly, the podophyllotoxin gem-difluorinated C-glycoconjugated derivatives display improved conformational and chemical stability, and improved cytotoxicity exhibited against drug-resistant cancer cell lines.