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临床前CDMO研发化合物筛选
Kynurenic acid
中文名称:犬尿喹啉酸
CAS号:492-27-3
分子式: C10H7NO3 分子量: 189.17
产品形式: free base
研发状态: Not yet recruiting
研发用途: Alcohol Use Disorder
研究机构: University of Maryland Baltimore
研发日期: Apr-24
研发阶段: Early Phase 1
Kynurenic acid (Quinurenic acid, Kynurenate), a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA
receptors.
Eliglustat
中文名称:依利格鲁司特
CAS号:491833-29-5
分子式: C23H36N2O4 分子量: 404.54
产品形式: Tartrate
研发状态: Completed
研发用途: Gaucher Disease Type 1
研究机构: Genzyme a Sanofi Company; Sanofi
研发日期: Nov-09
研发阶段: Phase 3
Eliglustat (GENZ-112638) inhibits glucosylceramide synthase(GCS) (IC50=20 nM in intact MDCK cells), thus reducing the load of glucosylceramide influx into the lysosome.
(-)Epicatechin
中文名称:表儿茶素(EC)
CAS号:490-46-0
分子式: C15H14O6 分子量: 290.27
产品形式: free base
研发状态: Recruiting
研发用途: Adults
研究机构: University of California Davis; Mars Inc.
研发日期: November 2 2023
研发阶段: --
(−)Epicatechin (L-Epicatechin, (-)-Epicatechol) is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.
Icariin
中文名称:淫羊藿苷
CAS号:489-32-7
分子式: C33H40O15 分子量: 676.66
产品形式: free base
研发状态: Completed
研发用途: the Pharmacokinetic Profile of Icariin in Humans
研究机构: University of Texas Southwestern Medical Center; National Center for Complementary and Integrative Health (NCCIH)
研发日期: Apr-14
研发阶段: Phase 1
Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.
Elesclomol (STA-4783)
中文名称:伊利司莫
CAS号:488832-69-5
分子式: C19H20N4O2S2 分子量: 400.50
产品形式: free base
研发状态: Suspended
研发用途: Metastatic Solid Tumors
研究机构: Synta Pharmaceuticals Corp.
研发日期: Jan-09
研发阶段: Phase 1
Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand and inhibits FDX1-mediated Fe-S cluster biosynthesis.
Ribitol
中文名称:侧金盏花醇
CAS号:488-81-3
分子式: C5H12O5 分子量: 152.15
产品形式: free base
研发状态: Withdrawn
研发用途: Diphtheria; Acellular Pertussis; Haemophilus Influenzae Type b; Tetanus; Poliomyelitis
研究机构: GlaxoSmithKline
研发日期: December 1 2017
研发阶段: Phase 3
Ribitol (Adonitol) is a crystalline pentose alcohol and is formed by the reduction of ribose which is occurs naturally in the plant Adonis vernalis.
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