临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 55589-62-3

Acesulfame Potassium

中文名称:安塞蜜
CAS号:55589-62-3
分子式: C4H5NO4S.K 分子量: 202.25
产品形式: Potassium Salt
研发状态: Active not recruiting
研发用途: Breastfeeding
研究机构: George Washington University
研发日期: February 28 2022
研发阶段: Not Applicable
Acesulfame potassium is a non-nutritive sweetener.

CAS: 55-56-1

Chlorhexidine

中文名称:氯己定
CAS号:55-56-1
分子式: C22H30Cl2N10 分子量: 505.45
产品形式: free base
研发状态: Recruiting
研发用途: Infections
研究机构: Duke University; Massachusetts General Hospital; Indiana University Health
研发日期: May 1 2024
研发阶段: Not Applicable
Chlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts.

CAS: 555-30-6

Methyldopa

中文名称:甲基多巴
CAS号:555-30-6
分子式: C10H13NO4 分子量: 211.21
产品形式: free base
研发状态: Active not recruiting
研发用途: AADC Deficiency
研究机构: PTC Therapeutics
研发日期: May 12 2021
研发阶段: Phase 2
Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.

CAS: 554-13-2

Lithium carbonate

中文名称:碳酸锂
CAS号:554-13-2
分子式: CLi2O3 分子量: 73.89
产品形式: Salt
研发状态: Recruiting
研发用途: Depressive; Disorder Major Single Episode Major With Psychotic Symptoms; Depressive; Disorder Major Single Episode Major (Without Psychotic Symptoms); Depressive Disorder Major Recurrent With Psychotic Symptoms; Depressive Disorder Major Recurrent Without Psychotic Symptoms; Depressive Disorder Treatment-Resistant Class I or II; Depressive Disorder Major Moderate; Depressive Disorder Major Severe
研究机构: Max-Planck-Institute of Psychiatry
研发日期: April 2 2024
研发阶段: --
Lithium carbonate (Li2CO3) is an inorganic compound that is valuable and effective agent in the treatment and prophylaxis of mood disorders, particularly bipolar disorder (BD). Lithium carbonate is able to alter D2 dopamine receptors response.

CAS: 553-12-8

Protoporphyrin IX

中文名称: 原卟啉
CAS号:553-12-8
分子式: C34H34N4O4 分子量: 562.66
产品形式: free base
研发状态: Enrolling by invitation
研发用途: Erythropoietic Protoporphyria
研究机构: Disc Medicine Inc
研发日期: August 31 2023
研发阶段: Phase 2 : Phase 3
Protoporphyrin IX (PPIX) is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway.

CAS: 55-31-2

Epinephrine HCl

中文名称:盐酸肾上腺素
CAS号:55-31-2
分子式: C9H13NO3.HCl 分子量: 219.67
产品形式: HCl
研发状态: Not yet recruiting
研发用途: Sepsis; Septic Shock
研究机构: Mansoura University
研发日期: Jun-24
研发阶段: Phase 2
Epinephrine HCl (Adrenaline) is a hormone and a neurotransmitter.