CAS: 55-56-1; 1,1'-Hexamethylenebis[5-(P-Chlorophenyl)Biguanide]

上下游产品

CAS号56-95-1 醋酸氯己定 | CAS号15894-70-9 1,6-双氰基胍基己烷 | CAS号20265-96-7 对氯苯胺盐酸盐 | CAS号6055-52-3 1,6-己二胺盐酸盐 | CAS号1482-62-8 1-(4-氯苯基)-3-氰基胍 | CAS号106-47-8 对氯苯胺

6-氨基-1-己烷氯化铵 以 乙二醇乙醚,正丁醇 作为反应溶剂,化学反应 12.5H,反应生成 氯己定
参考文献:口腔消毒剂抑制抗凋亡蛋白bcl-Xl介导的蛋白质-蛋白质相互作用,并诱导人口腔肿瘤细胞凋亡.
标题:口腔消毒剂抑制抗凋亡蛋白bcl-Xl介导的蛋白质-蛋白质相互作用,并诱导人口腔肿瘤细胞凋亡.
摘要:长期以来,洗必泰和阿莱西丁已被人类用作口服消毒剂.两种化合物均在生理相关浓度下抑制抗凋亡蛋白bcl-X L介导的蛋白-蛋白相互作用,并诱导一系列源自舌头和咽部的肿瘤细胞系的凋亡(见图).抑制蛋白质之间的相互作用是当前人类使用药物的一种潜在作用方式.
DOI:10.1002/anie.201208889

专利信息

专利号:US-2024358747-A1
优先权日:2021-09-01
标 题:SOME GEL FORMULATIONS THAT PROVIDE WOUND HEALING AND THE SYNTHESIS OF DYSPROSIUM ERBIUM BORATE TRIHYDRATE (Dy0.5Er0.5BO3.3H2O) COMPOUND USED IN THESE FORMULATIONS
发明人：UYSAL AYSE ECEM
权利人:VERTRATECH KIMYA SANAYI VE TICARET LTD SIRKETI
摘要:Disclosed is a gel formulation, in which boric acid, metal borate and hyaluronic acid derivatives are used together as an active ingredient, which is rapidly absorbed from the skin, effectively accelerating the skin's self-renewal, removal of redness and scar-free wound healing processes. Additionally disclosed is the synthesis of a novel amorphous, nanostructured bimetallic compound of dysprosium erbium borate trihydrate used in this formulation.

专利号:US-12221452-B2
优先权日:2017-10-04
标题:Synthesis of cantharidin
发明人：DAVIDSON MATTHEW GENE; EKLOV BRIAN MATTHEW; WUTS PETER; LOERTSCHER BRAD MELVIN; SCHOW STEVEN R
权利人:VERRICA PHARMACEUTICALS INC
摘要:The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions (e.g., infectious diseases and skin conditions).

专利号:US-8815351-B2
优先权日:2005-09-15
标 题:Method for attachment of silicon-containing compounds to a surface and for synthesis of hypervalent silicon-compounds
发明人：OWENS JEFFREY R
权利人:OWENS JEFFREY R; US AIR FORCE
摘要:A method for attaching silicon-containing compounds to a surface and for synthesis of hypervalent silicon-compounds is described. Attaching silicon-containing compounds to a surface comprises providing a silicon-containing compound having two or more leaving groups, and a first functional compound comprising at least one nucleophilic group, contacting the silicon-containing compound and the functional compound with a surface of a substrate having nucleophilic sites and exposing the silicon-containing compound, the functional compound and the surface of the substrate to microwave radiation.

专利号:WO-2017137818-A1
优先权日:2016-02-12
标 题 :Synthesis and application of an antimicrobial active
发明人：K RAKESH RATNAM; SARVIYA SAMIR
权利人:SALICYLATES & CHEMICALS
摘要:The disclosure Synthesis & Application of a Novel Antimicrobial active provides a method of synthesis of organic complex starting from fatty acid with a free base bioactive molecule containing nitrogen atoms. The reaction is usually conducted in refluxing alcohol. The product is synthesized by a acid-base reaction whereby the acid molecule is capable of donating a proton, to the free base molecule resulting in the formation of the desired complex. These complexes are very effective antimicrobial active against a variety of bacteria, fungi, protozoa, helminths and viruses. The process is suitable for large-scale synthesis and involves simple and high-yielding techno feasible chemical transformations using low-cost commercially available raw materials. The complex has wide spread use in human personal care, industries and household applications, as the disclosed chemical has antimicrobial activity against gram positive, gram negative bacteria, yeast, mold, fungi.

专利号:US-11155562-B2
优先权日:2014-06-30
标 题 :Synthesis of halichondrin analogs and uses thereof
发明人：KISHI YOSHITO; UEDA ATSUSHI; YAMAMOTO AKIHIKO; KATO DAISUKE
权利人:HARVARD COLLEGE
摘要:The present invention provides halichondrin analogs, such as compounds of Formula (I). The compounds may bind to microtubule sites, thereby inhibiting microtubule dynamics. Also provided are methods of synthesis, pharmaceutical compositions, kits, methods of treatment, and uses that involve the compounds for treatment of a proliferative disease (e.g., cancer). Compounds of the present invention are particularly useful for the treatment of metastatic breast cancer, non-small cell lung cancer, prostate cancer, and sarcoma. The included methods of synthesis are useful for the preparation of compounds of Formula (I)-(III) along with naturally occurring halicondrins (e.g., halichondrin B & C, norhalichondrin A, B, & C, and homohalichondrin A, B, & C). Also included are methods for interconverting between the halichondrins, norhalichondrins, and homohalichondrins and their unnatural epimers at the C38 ketal stereocenter through the use of an acid-mediated equilibration.

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.