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临床前CDMO研发化合物筛选
Praziquantel
中文名称:吡喹酮
CAS号:55268-74-1
分子式: C19H24N2O2 分子量: 312.41
产品形式: free base
研发状态: Not yet recruiting
研发用途: Cholangiocarcinoma; Liver Fluke-Related Cholangiocarcinoma; Opisthorchiasis
研究机构: McMaster University; Khon Kaen University; Global Alliance for Chronic Diseases (GACD); Canadian Institutes of Health Research (CIHR)
研发日期: July 1 2024
研发阶段: Not Applicable
Praziquantel is an anthelmintic effective against flatworms.
Rolapitant
中文名称:罗拉吡坦
CAS号:552292-08-7
分子式: C25H26F6N2O2 分子量: 500.48
产品形式: NK1 receptor antagonists
研发状态: Completed
研发用途: Chemo-radiation Induced Nausea and Vomiting
研究机构: Duke University
研发日期: October 9 2017
研发阶段: Phase 2
Rolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.
Benzamide
中文名称:苯甲酰胺
CAS号:55-21-0
分子式: C7H7NO 分子量: 121.14
产品形式: free base
研发状态: Completed
研发用途: Advanced Solid Tumors
研究机构: Sanofi
研发日期: Jul-10
研发阶段: Phase 1
Benzamide, a derivative of benzoic acid, is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM.
Dexamethasone Sodium Phosphate
中文名称:地塞米松磷酸钠
CAS号:55203-24-2
分子式: C22H30FO8P.2Na 分子量: 516.40
产品形式: Disodium salt
研发状态: Not yet recruiting
研发用途: Relapsed and/or Refractory Multiple Myeloma
研究机构: Adriana Rossi; Icahn School of Medicine at Mount Sinai
研发日期: June 3 2024
研发阶段: Phase 1 : Phase 2
Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
N-Nitrosodiethylamine
中文名称:N-二乙基亚硝胺
CAS号:55-18-5
分子式: C4H10N2O 分子量: 102.14
产品形式: Free Base
研发状态: Not yet recruiting
研发用途: Werner Syndrome
研究机构: PRG Science & Technology Co. Ltd.
研发日期: January 1 2025
研发阶段: Phase 2
N-Nitrosodiethylamine (N-Nitroso-diethylamine, NDEA, diethylnitrosamine, DEN) is DNA reactive after bioactivation and produces tumors in many animal species.
Encenicline (EVP-6124) hydrochloride
中文名称:(R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺盐酸盐
CAS号:550999-74-1
分子式: C16H17ClN2OS.ClH 分子量: 357.30
产品形式: hydrochloride
研发状态: Withdrawn
研发用途: Alzheimer''s Disease; Dementia; Cognition
研究机构: FORUM Pharmaceuticals Inc; Quintiles Inc.
研发日期: Jul-15
研发阶段: Phase 2
Encenicline (EVP-6124) hydrochloride is a selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.
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