CAS: 55-18-5; N-Nitrosodiethylamine

该化合物是一种含有分子式C4H10N2O的硝酸胺化合物.主要用于研究和工业应用,特别是由于其有充分证据的诱变和诱变特性,在毒理学研究中作为示范致癌物.NDEA还用于化学合成,并作为分析化学的参考标准,用于检测药物和消费品中的硝酸胺杂质.在受管制条件下,其高反应性和稳定性使其成为研究硝酸胺形成机制的宝贵工具.适当处理至关重要,因为NDEA被归类为强致癌物,需要严格的安全议定书来尽量减少接触风险.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

pyridine tetranitromethane triethylamine N1,N1,N3,N3-tetraethyl-propane-1,2,3-triyltriamineN1,N1,N3,N3-tetraethyl-propane-1,2,3-triyltriamineethane aldehyde diethylhydrazone N,N-diethyl-N'-phenyl-hydrazineN,N-diethyl-N'-phenyl-hydrazine Ethyl-vinyl-nitrosamin

合成工艺路线路线简述

    Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于potassium Nitrite体系中,化学反应生成 N-亚硝基二乙胺
    参考文献:Geuther; Kreutzhage,Justus Liebigs Annalen Der Chemie,1863,Vol. 128,P. 151
    标题:Geuther; Kreutzhage,Justus Liebigs Annalen Der Chemie,1863,Vol. 128,P. 151

    海关参考信息

    专利信息


    专利号:WO-2023046836-A1
    优先权日:2021-09-24
    标 题:Process for preparing sartans
    发明人:ZUPANCIC SILVO; SENICAR TANJA; PERÅ E BOÅ TJAN; BOMBEK SERGEJA; KLOBCAR ANDREJ; KRAÅ OVEC DuÅ¡an
    权利人:KRKA D D NOVO MESTO
    摘要:The present application relates to a process for purifying a tetrazole-containing-sartan or a tetrazole-containing-sartan intermediate, the process comprising the steps of (a) providing a composition comprising an azide-impurity together with a tetrazole-containing-sartan or with an intermediate of a tetrazole-containing-sartan; (b) treating the composition provided in step (a) with a reducing agent; preferably reacting the azide-impurity with a reducing agent thereby obtaining an amine-impurity; and (c) optionally, isolating the tetrazole-containing-sartan or the intermediate of the tetrazole-containing-sartan from the composition. The application further relates to a process for the synthesis of tetrazole-containing-sartans which ensures azide-impurities free final active pharmaceutical ingredients as well as azide-impurities free intermediates of tetrazole-containing-sartans that are suitable for the subsequent synthesis of tetrazole-containing-sartans.

    专利号:WO-2023040981-A1
    优先权日:2021-09-20
    标 题:Methods and compositions for weight management
    发明人:HUA NG MENG; WANG RUIQI RACHEL; LIANG KUN; ZHENG ZIPENG; YANG JIE
    权利人:AEGOGEN SUZHOU LTD
    摘要:This present application relates to the use of small molecules for weight management, prevention of aging and the treatment of associated conditions and diseases. The present application also provides for the synthesis of some of the molecules and the administration of these molecules for drug discovery, nutrition and cosmeceutical purposes.

    专利号:JP-H07327699-A
    优先权日:1994-06-09
    标 题:Simultaneous detection of repair DNA synthesis amount and replication DNA synthesis amount of cells

    专利号:US-12145861-B2
    优先权日:2018-01-11
    标 题 :Water purification process using zinc oxide nanoparticles
    发明人:QURESHI FAIZA; NAWAZ MUHAMMAD
    权利人:UNIV IMAM ABDULRAHMAN BIN FAISAL
    摘要:A method of using ZnO particles for the treatment of colon cancer and a method of using the particles for reducing the concentration of an organic contaminant in an aqueous solution is described. The ZnO particles are substantially spherical and may have nanopetals that provide a nanoflower morphology. The synthesis and characterization of the ZnO particles is also discussed.

    专利号:DE-102008026714-A1
    优先权日:2008-06-04
    标题 :Process for the preparation of oxide-based organometallic frameworks by inverse synthesis

    专利号:CN-110646531-A
    优先权日:2019-09-18
    标题 :A kind of ion chromatography quantitative analysis method of raw material diethanolamine in diethanolamine dehydrogenation synthesis iminodiacetic acid reaction solution
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    合成参考文献


    参考文献:10.1007/s00228-010-0785-6
    摘要:Djordjevic N, Carrillo JA, Gervasini G, Jankovic S, Aklillu E. In vivo evaluation of CYP2A6 and xanthine oxidase enzyme activities in the Serbian population. European Journal of Clinical Pharmacology. 2010 Feb 13;66(6):571–8. doi: 10.1007/s00228-010-0785-6.
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    参考文献:10.1158/1078-0432.ccr-10-1734
    摘要:Jiang R, Deng L, Zhao L, Li X, Zhang F, Xia Y, Gao Y, Wang X, Sun B. miR-22 promotes HBV-related hepatocellular carcinoma development in males. Clin Cancer Res. 2011 Sep 01;17(17):5593–603. doi: 10.1158/1078-0432.ccr-10-1734.
    参考文献:10.4061/2011/361304
    摘要:Rosen MD, Privalsky ML. Thyroid Hormone Receptor Mutations in Cancer and Resistance to Thyroid Hormone: Perspective and Prognosis. Journal of Thyroid Research. 2011;2011():1–20. doi: 10.4061/2011/361304.
    参考文献:10.1089/jmf.2010.1459
    摘要:Chen K, Lin B, Chien C, Ho C. Emblica officinalis Gaertn. Attentuates N -Nitrosodiethylamine-Induced Apoptosis, Autophagy, and Inflammation in Rat Livers. Journal of Medicinal Food. 2011 Jul;14(7-8):746–55. doi: 10.1089/jmf.2010.1459.
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