专利号:WO-2023046836-A1 优先权日:2021-09-24 标 题:Process for preparing sartans 发明人:ZUPANCIC SILVO; SENICAR TANJA; PERÅ E BOÅ TJAN; BOMBEK SERGEJA; KLOBCAR ANDREJ; KRAÅ OVEC DuÅ¡an 权利人:KRKA D D NOVO MESTO 摘要:The present application relates to a process for purifying a tetrazole-containing-sartan or a tetrazole-containing-sartan intermediate, the process comprising the steps of (a) providing a composition comprising an azide-impurity together with a tetrazole-containing-sartan or with an intermediate of a tetrazole-containing-sartan; (b) treating the composition provided in step (a) with a reducing agent; preferably reacting the azide-impurity with a reducing agent thereby obtaining an amine-impurity; and (c) optionally, isolating the tetrazole-containing-sartan or the intermediate of the tetrazole-containing-sartan from the composition. The application further relates to a process for the synthesis of tetrazole-containing-sartans which ensures azide-impurities free final active pharmaceutical ingredients as well as azide-impurities free intermediates of tetrazole-containing-sartans that are suitable for the subsequent synthesis of tetrazole-containing-sartans.
专利号:WO-2023040981-A1 优先权日:2021-09-20 标 题:Methods and compositions for weight management 发明人:HUA NG MENG; WANG RUIQI RACHEL; LIANG KUN; ZHENG ZIPENG; YANG JIE 权利人:AEGOGEN SUZHOU LTD 摘要:This present application relates to the use of small molecules for weight management, prevention of aging and the treatment of associated conditions and diseases. The present application also provides for the synthesis of some of the molecules and the administration of these molecules for drug discovery, nutrition and cosmeceutical purposes.
专利号:JP-H07327699-A 优先权日:1994-06-09 标 题:Simultaneous detection of repair DNA synthesis amount and replication DNA synthesis amount of cells
专利号:US-12145861-B2 优先权日:2018-01-11 标 题 :Water purification process using zinc oxide nanoparticles 发明人:QURESHI FAIZA; NAWAZ MUHAMMAD 权利人:UNIV IMAM ABDULRAHMAN BIN FAISAL 摘要:A method of using ZnO particles for the treatment of colon cancer and a method of using the particles for reducing the concentration of an organic contaminant in an aqueous solution is described. The ZnO particles are substantially spherical and may have nanopetals that provide a nanoflower morphology. The synthesis and characterization of the ZnO particles is also discussed.
专利号:DE-102008026714-A1 优先权日:2008-06-04 标题 :Process for the preparation of oxide-based organometallic frameworks by inverse synthesis
专利号:CN-110646531-A 优先权日:2019-09-18 标题 :A kind of ion chromatography quantitative analysis method of raw material diethanolamine in diethanolamine dehydrogenation synthesis iminodiacetic acid reaction solution
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