CAS: 55268-74-1; 2-(Cyclohexanecarbonyl)-2,3,6,7-Tetrahydro-1H-Pyrazino[2,1-A]Isoquinolin-4(11Bh)-One

相似化合物

57452-97-8 55375-92-3 61196-37-0

上下游产品

CAS号79848-93-4 N-((1,2,3,4-dih... | CAS号79-04-9 氯乙酰氯 | CAS号2719-27-9 环己甲酰氯 | CAS号61196-37-0 DL-吡喹胺 | CAS号2043-61-0 环己烷甲醛 | CAS号87693-75-2 4-(cyclohexanec... | CAS号98-89-5 环己甲酸 | CAS号5234-86-6 2,3,4,6,7,11b-六... | CAS号61196-37-0 DL-吡喹胺 | CAS号61196-40-5 2-acetyl-3,6,7,...

N-(2-Oxoethyl)-N-[2-Oxo-2-(2-Phenylethylamino)Ethyl]Cyclohexanecarboxamide置于三氟乙酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 10.0H,以76.8%的收率获得产物吡喹酮
参考文献:Preparation Method For Praziquantel And Intermediate Compounds Thereof
标题:Preparation Method For Praziquantel And Intermediate Compounds Thereof
摘要:揭示了一种吡喹酮及其中间体的制备方法.该方法包括:通过将β-苯乙胺与氯乙酰氯进行缩合反应,与乙醇胺进行取代反应,以及与环己基甲酰氯进行酰化反应,得到目标产品吡喹酮,随后进行氧化反应和环化反应.还揭示了两个关键中间体,即式iv的化合物和式v的化合物,用于制备吡喹酮.该制备方法在技术设计上合理简单,使用适中的反应条件,经济环保.此外,原料价格低廉且易获得,关键中间体易于制备,获得的目标化合物吡喹酮的总反应产率和纯度高,便于实现工业化大规模生产.

专利信息

专利号:EP-3480195-A1
优先权日:2017-11-07
标 题:Method for the synthesis of cyclic depsipeptides
权利人:BAYER ANIMAL HEALTH GMBH; THE KITASATO INST
摘要:The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, involving specific carboxylic acid group protecting tags: nTAG is preferably: nwherein m is ‰¥ 15 to ‰¤ 25, p is ‰¥ 8 to ‰¤ 18 and q is ‰¥ 15 to ‰¤ 25.

专利号:US-12122759-B2
优先权日:2017-11-07
标 题:Method for the synthesis of cyclic depsipeptides
发明人：HEIMBACH DIRK; OMURA SATOSHI; SUNAZUKA TOSHIAKI; HIROSE TOMOYASU; NOGUCHI YOSHIHIKO; Köbberling Johannes; WU ZHIJIE; FU SHUIBIAO; WU WEI; QIU JINFENG; HE LIU; WEI XUDONG
权利人:ELANCO ANIMAL HEALTH GMBH; THE KITASATO INST
摘要:The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.

专利号:US-9802934-B2
优先权日:2013-10-17
标 题 :Process for the synthesis of (R)-praziquantel
发明人：QIAN MINGXIN
权利人:TONGLI BIOMEDICAL CO LTD
摘要:The present disclosure relates to a process and new intermediates for the synthesis of (R)-praziquantel, which is obtained through four steps in proper order, that is, condensation reaction, reduction reaction, acylation reaction and ring-closing reaction, using (1R)-2-substituted-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid as starting material. Overall, the present disclosure provides a (R)-praziquantel product with higher optical purity through a process route that is more cost effective and environmentally friendly.

专利号:WO-2009115333-A1
优先权日:2008-03-20
标 题:Novel synthesis of praziquantel
发明人：DOEMLING ALEXANDER
权利人:DOEMLING ALEXANDER
摘要:The present invention discloses a novel and efficient synthesis of praziquantel (I).

专利号:US-9409879-B2
优先权日:2011-03-29
标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
发明人：DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA
权利人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA; CENTRE NAT RECH SCIENT
摘要:Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.

专利号:US-4814347-A
优先权日:1985-07-22
标 题:Anthelmintic spiroketals and method of use
发明人：NELSON STEPHEN J
权利人:UPJOHN CO
摘要:This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.