在 水,Potassium Hydroxide体系中,用 二氯甲烷,水作为反应溶剂,反应 0.5H,获得 Potassium Acesulfame 参考文献:Acesulfame Potassium Compositions And Processes For Producing Same 标题:Acesulfame Potassium Compositions And Processes For Producing Same 摘要:描述了生产高纯度乙酰磺酸钾的组合物和工艺.其中一种工艺包括以下步骤:提供含有乙酰磺酸钾和乙酰乙酰胺的粗乙酰磺酸钾组合物,浓缩粗乙酰磺酸钾组合物以形成水流和含有乙酰磺酸钾和少于33 Wppm乙酰乙酰胺的中间乙酰磺酸钾组合物,分离中间乙酰磺酸钾组合物以形成成品乙酰磺酸钾组合物,其中成品乙酰磺酸钾组合物含有乙酰磺酸钾和少于33 Wppm乙酰乙酰胺.浓缩步骤在90°c以下的温度下进行,分离步骤在35°c或以下的温度下进行.
专利号:US-2023089537-A1 优先权日:2021-09-20 标题:Dietary supplement and method for synthesis of same 发明人:WYNN JASON R 权利人:StrongCell LLC 摘要:A dietary supplement and method for synthesis of the same are disclosed. In one embodiment of the method, an NADH component is provided which includes NADH from about 0.1% to about 0.5% blended with water from about 40% to about 84% both by weight of the dietary supplement. A supplement component from about 9% to about 99% by weight of the dietary supplement is also provided. The supplement component may include collagen in about 2% to about 10%, vitamins in about 0.00001% to about 3%, and minerals in about 0.000002% to about 0.5% all by weight of the dietary supplement. A mixed component is formed by mixing the NADH component with the supplement component at ambient conditions. The mixed component is a liquid at ambient conditions having a pH of less than 4.0. The mixed component is subjected to a cold fill production process.
专利号:US-5225591-A 优先权日:1992-07-28 标题 :Process for making 1-cyclopentylalyl amines useful for the synthesis of sweeteners 发明人:SWEENY JAMES G; D ANGELO LIHONG L 权利人:COCA COLA CO 摘要:The disclosed process relates to a method for preparing 1-cyclopentylalkyl amines, useful in the synthesis of artificial sweeteners, by reducing an azanorbornene in a high-yield one-step reduction of an azanorbornene, wherein the method involves use of a solvent reductant system with catalyst that is compatible with the production of edible food compositions.
专利号:US-2006030625-A1 优先权日:2004-08-06 标 题 :Dietary neurotransmitter precursors for balanced synthesis of neurotransmitters 发明人:HART CHERYLE RAM; GROSSMAN RONALD S; RAM HERBERT 权利人:HART CHERYLE RAM; GROSSMAN RONALD S; RAM HERBERT 摘要:Dietary supplements for treating a neurotransmitter deficiency include one or more precursors of the deficient neurotransmitter and a cofactor for activating in vivo enzymatic synthesis of the deficient neurotransmitter. The dietary supplements can also include an appropriate neurotransmitter, such as an amino acid. When administered through the oral mucosa, increases in levels of the deficient neurotransmitters and relief from deficiency symptoms are obtained.
专利号:US-12043612-B2 优先权日:2020-05-09 标 题 :Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same 发明人:ALLAN LAURA E N; CHEN CHUNGPIN HERMAN; DONG HANQING; GROSSO JOHN A; HASKELL III ROYAL J; LLOYD RHYS; REECE HAYLEY 权利人:ARVINAS OPERATIONS INC 摘要:The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A:The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.
专利号:US-2017204442-A1 优先权日:2014-05-29 标题 :Enzymatic synthesis of soluble glucan fiber 发明人:DICOSIMO ROBERT; CHENG QIONG; ELIOT ANDREW C; OUWEHAND ARTHUR; PAYNE MARK S; YOU ZHENG 权利人:DU PONT 摘要:An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.
专利号:US-8182756-B2 优先权日:2006-09-24 标题:Apparatus for producing an intermediate in the synthesis of acesulfame potassium 发明人:LIU JICAI; KONG LINGWEN; BAO ZHONGXIANG; CHEN XIAOPING 权利人:LIU JICAI; KONG LINGWEN; BAO ZHONGXIANG; CHEN XIAOPING; SUZHOU HOPE TECHNOLOGY CO LTD 摘要:The invention discloses a kind of sulfonation cyclization technique for synthesizing acesulfame potassium for continuous production without stirring and special equipment for this technique. An injection pump is adopted to directly inject the sulfonation raw material and sulfonating agent into autoclave for sulfonation cyclization reaction under high velocity. Moreover, the reciprocating pump is adopted to deliver part of materials in autoclave to condenser designed outside the autoclave for cooling, followed by delivering the cooled materials to another input end of injection pump which together with sulfonation raw material and sulfonating agent is injected into autoclave through high-velocity injection by injection pump. The apparatus is composed of autoclave, injection pump, reciprocating pump and condenser.
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合成参考文献
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