CAS: 55-31-2; (R)-Adrenaline Hydrochloride

以 氘代甲醇,重水 作为反应溶剂,化学反应生成 盐酸肾上腺素,
参考文献:迈向合成肾上腺素受体-形状选择性肾上腺素在水中的识别.
标题:迈向合成肾上腺素受体-形状选择性肾上腺素在水中的识别.
摘要:一种经过合理设计的新受体分子结合了水中的肾上腺素衍生物.它的结合模式模仿了天然受体中非共价相互作用的相互作用.对于纤细的多巴胺骨架,可以实现较高的形状选择性,并导致具有α取代基的底物(如氨基酸衍生物)被排斥.
DOI:10.1002/1521-3773(20010903)40:17<3148::Aid-Anie3148>3.0.Co;2-S

专利信息

专利号:US-11053227-B2
优先权日:2017-12-20
标 题:Process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction and novel synthesis intermediates
发明人：COLLI CORRADO; BERTOLINI GIORGIO; SADA MARA; GARIS FARIS; NISIC FILIPPO; BIANCHI ALDO; BIAGGI CINZIA; DI FABIO ROMANO; RONZONI SILVANO; BERTUOLO STEFANIA; PRANDI ADOLFO; MAIORANA STEFANO
权利人:OLON SPA
摘要:Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.

专利号:US-5043328-A
优先权日:1986-05-09
标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems
发明人：WEITHMANN KLAUS U
权利人:HOECHST AG
摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.

专利号:US-8017776-B2
优先权日:2003-07-15
标题 :Methods for synthesis of acyloxyalkyl compounds
发明人：BHAT LAXMINARAYAN; GALLOP MARK A
权利人:XENOPORT INC
摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

专利号:US-6726911-B1
优先权日:1999-03-09
标 题 :Biologically active compounds of Ganoderma pfeifferi DSM 13239
发明人：JUELICH WOLF; LINDEQUIST ULRIKE; JANSEN ROLF; MOTHANA RAMZI
权利人:GANOMYCIN
摘要:The present invention relates to novel biologically active compounds from fungi of the species Ganoderma pfeifferi DSM 13239, processes for their preparation, and their use. From the fruit body and mycelium of the species Ganoderma pfeifferi DSM 13239, extracts can be obtained which have antimicrobial activity and are suitable as preserving agents, for pharmaceutical and cosmetic preparations, for controlling infections, and for use in fish breeding. Antimicrobially active substances called ganomycins having activity against multiresistant germs are isolated from the extracts. The total synthesis of the ganomycins and their derivatization enables their use an antibiotics.

专利号:US-6390453-B1
优先权日:1997-10-22
标题 :Method and apparatus for delivery of fragrances and vapors to the nose
发明人：FREDERICKSON CHRISTOPHER J; HAYES DONALD J; WALLACE DAVID B; TAYLOR DAVID W; HAYES MATTHEW D
权利人:MICROFAB TECH INC
摘要:A method and apparatus is disclosed which employs a pulse-controlled microdroplet fluid delivery system for precisely dispensing fragrances and other odor producing vapors. The pulse-controlled fluid delivery device is capable of ejecting microdroplets of fluid with a diameter less than 350 micrometers at a controlled ejection rate based upon ink-jet printing technology. The pulse-controlled fluid delivery system includes mechanisms for vaporizing the fluids and delivery of the vapors to the nose, which is controlled by a programmable system controller capable of real time data-driven dispensing with a multi-fluid capability. Synthesis of custom fragrances is made possible by a multijet programmed control system which adjusts dispensing rates of components. Calibration of a prior art “electronic noseâ€? is disclosed. A precise calibration gas is produced in real-time to counteract the effect of drifting.

专利号:US-6672129-B1
优先权日:1997-10-22
标 题:Method for calibrating a sensor for measuring concentration of odors
发明人：FREDERICKSON CHRISTOPHER J; HAYES DONALD J; WALLACE DAVID B; TAYLOR DAVID W; HAYES MATTHEW D
权利人:MICROFAB TECH INC
摘要:A method and apparatus is disclosed which employs a pulse-controlled microdroplet fluid delivery system for precisely dispensing fragrances and other odor producing vapors. The pulse-controlled fluid delivery device is capable of ejecting microdroplets of fluid with a diameter less than 350 micrometers at a controlled ejection rate based upon inkjet printing technology. The pulse-controlled fluid delivery system includes mechanisms for vaporizing the fluids and delivery of the vapors to the nose, which is controlled by a programmable system controller capable of real time data-driven dispensing with a multi-fluid capability. Synthesis of custom fragrances is made possible by a multijet programmed control system which adjusts dispensing rates of components. Calibration of a prior art 'electronic nose' is disclosed. A precise calibration gas is produced in real-time to counteract the effect of drifting.