新项目精选

近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式：PROTAC/分子胶降解剂：通过诱导靶蛋白泛素化降解发挥作用，而非传统“占位驱动”抑制。这类分子的项目整合需要同时考量靶点配体、E3连接酶配体及连接子的三元复合物优化，临床前到临床的转化难度显著增加。多肽/环肽药物：介于小分子与生物制品之间，兼具高选择性与口服可用性潜力。项目整合中需重点解决稳定性、递送及生产工艺放大问题。抗体-药物偶联物（ADC）：作为“生物导弹”，ADC的项目整合涉及抗体、连接子、有效载荷三部分的协同优化，需要跨学科团队的深度整合。小核酸药物（siRNA/ASO）：通过基因沉默机制发挥作用，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。展望未来，新型API项目的整合将呈现以下趋势：第一，AI贯穿全链条。从靶点发现、分子优化到临床开发、上市后监测，AI将成为贯穿API全生命周期的核心工具。第二，数据资产化。临床研究数据和真实世界数据将从“辅助工具”升级为“核心资产”，数据驱动的决策将成为项目整合的标准范式。第三，开放整合生态。API经济的成熟正在推动制药企业从“封闭研发”走向“开放协作”，通过API接口与外部数据源、技术平台、CRO/CDMO实现无缝对接. 而API技术——无论是数据接口还是组织协作的“应用程序接口”——正成为支撑这一整合的核心基础设施。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

新项目整合精选

新产品编号:1856195

Chemical Name: 3-Fluoro-4-[1(R)-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol oxalate
项目整合开发状态: Biological Testing
项目研究机构: National Institutes of Health (Originator), Westf鋖ische Wilhelms-Univ. ...
参考文献标题:Syntheses of (R)- an (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: Effect of stereochemistry on fluorine-induced adrenergic selectivities
文献作者:Lu,S.; Herbert,B.; Haufe,G.; Wilhelm Laue,K.; Padgett,W.L.; Oskunleti,O.; Daly,J.W.; Kirk,K.L.
参考来源:J Med Chem 2000,43(8),1611

新产品编号:1857777

Chemical Name: 3-Fluoro-4-[1(S)-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol oxalate
项目整合开发状态: Biological Testing
项目研究机构: National Institutes of Health (Originator), Westf鋖ische Wilhelms-Univ. ...
参考文献标题:Syntheses of (R)- an (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: Effect of stereochemistry on fluorine-induced adrenergic selectivities
文献作者:Lu,S.; Herbert,B.; Haufe,G.; Wilhelm Laue,K.; Padgett,W.L.; Oskunleti,O.; Daly,J.W.; Kirk,K.L.
参考来源:J Med Chem 2000,43(8),1611

新产品编号:1859359

Chemical Name: 4-Fluoro-5-[1(R)-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol oxalate
项目整合开发状态: Biological Testing
项目研究机构: National Institutes of Health (Originator), Westf鋖ische Wilhelms-Univ. ...
参考文献标题:Syntheses of (R)- an (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: Effect of stereochemistry on fluorine-induced adrenergic selectivities
文献作者:Lu,S.; Herbert,B.; Haufe,G.; Wilhelm Laue,K.; Padgett,W.L.; Oskunleti,O.; Daly,J.W.; Kirk,K.L.
参考来源:J Med Chem 2000,43(8),1611

新产品编号:1860941

Chemical Name: 4-Fluoro-5-[1(S)-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
项目整合开发状态: Biological Testing
项目研究机构: National Institutes of Health (Originator), Westf鋖ische Wilhelms-Univ. M黱ster (...
参考文献标题:Syntheses of (R)- an (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: Effect of stereochemistry on fluorine-induced adrenergic selectivities
文献作者:Lu,S.; Herbert,B.; Haufe,G.; Wilhelm Laue,K.; Padgett,W.L.; Oskunleti,O.; Daly,J.W.; Kirk,K.L.
参考来源:J Med Chem 2000,43(8),1611

新产品编号:1862523

Chemical Name: 3-[13(R)-Acetoxy-13-[octahydro-5'(R)-[1(S)-acetoxy-5(S)-(2,3,4,6-O-tetrakis(acetyl)-beta-D-glucopyranosyloxy)undecyl][2(R),2'(R)-bifuran-5(R)-yl]tridecyl]-5(S)-methyl-2(5H)-furanone
...
参考文献标题:Synthesis,spectroscopy,and cytotoxicity of glycosylated acetogenin derivatives as promising molecules for cancer therapy
文献作者:Queiroz,E.F.; Roblot,F.; Duret,P.; Figad鑢e,B.; Gouyette,A.; Lapr関ote,O.; Serani,L.; Hocquemiller,R.
参考来源:J Med Chem 2000,43(8),1604

新产品编号:1864105

Chemical Name: 5(RS)-(6-Methoxy-1,2-benzoquinon-4-yl)-5,9,9a(SR),10-tetrahydro-7H-1,3-dioxolo[4,5-g]oxazolo[3,4-b]isoquinolin-7-one
项目整合开发状态: Biological Testing
项目研究机构: Gifu Pharmaceutical Unive...
参考文献标题:Podophyllotoxin aza-analogue,a novel DNA topoisomerase II inhibitor
文献作者:Iida,A.; Kano,M.; Kubota,Y.; Koga,K.; Tomioka,K.
参考来源:Chem Pharm Bull 2000,48(4),486

新产品编号:1865687

Chemical Name: N1,N2-Bis(2-quinolinylmethyl)ethane-1,2-diamine tetrahydrochloride
项目整合开发状态: Biological Testing
项目研究机构: Nara Women's University (Originator)
合成路线:Benzylic bromination of 2-meth...
参考文献标题:Effect of the linking position of a side chain in bis (quinolymethyl)ethylenediamine as a DNA binding agent
文献作者:Mikata,Y.; Onchi,Y.; Kishigami,M.; Yano,S.
参考来源:Chem Pharm Bull 2000,48(4),477

新产品编号:1867269

Chemical Name: N1,N2-Bis(8-quinolinylmethyl)ethane-1,2-diamine tetrahydrochloride
项目整合开发状态: Biological Testing
项目研究机构: Nara Women's University (Originator)
合成路线:Benzylic bromination of 2-meth...
参考文献标题:Effect of the linking position of a side chain in bis (quinolymethyl)ethylenediamine as a DNA binding agent
文献作者:Mikata,Y.; Onchi,Y.; Kishigami,M.; Yano,S.
参考来源:Chem Pharm Bull 2000,48(4),477

新产品编号:1868851

Chemical Name: [(1S,3S)-3-(6-Amino-9H-purin-9-yl)-1-fluorocyclopentyl]methanol; L-(1'S,3'S)-9-[3-Fluoro-3-(hydroxymethyl)cyclopentyl]adenine
项目整合开发状态: Biological Testing
项目研究机构: University of Ge...
参考文献标题:Stereoselective synthesis of carbocyclic L-4'-fluoro-2',3'-dideoxyadenosine
文献作者:Gumina,G.; Chong,Y.; Choi,Y.; Chu,C.K.
参考来源:Org Lett 2000,2(9),1229

HI-244

Chemical Name: N-(5-Bromopyridin-2-yl)-N'-[2-(4-methylphenyl)ethyl]thiourea
项目整合开发状态: Biological Testing
项目研究机构: Parker Hughes Institute (Originator)
合成路线:Reaction of 2-amino-5-bromopyridine ...
参考文献标题:Phenethyl-thiourea cpds.and use
文献作者:Ventalachalam,T.K.; Uckum,F.M.(Parker Hughes Institute)
参考来源:US 6207688