HI-244
Chemical Name: N-(5-Bromopyridin-2-yl)-N'-[2-(4-methylphenyl)ethyl]thiourea
项目整合开发状态: Biological Testing
项目研究机构: Parker Hughes Institute (Originator)
合成路线:Reaction of 2-amino-5-bromopyridine (I) with thiocarbonyldiimidazole (II) afforded the thioimidazolide (III).This was then condensed with 4-methylphenetylamine (IV) in hot DMF to produce the required thiourea.
📌 参考资料/链接：
参考文献标题:Phenethyl-thiourea cpds.and use
文献作者:Ventalachalam,T.K.; Uckum,F.M.(Parker Hughes Institute)
参考来源:US 6207688
📄 详细内容
合成路线:Reaction of 2-amino-5-bromopyridine (I) with thiocarbonyldiimidazole (II) afforded the thioimidazolide (III).This was then condensed with 4-methylphenetylamine (IV) in hot DMF to produce the required thiourea.
参考文献标题:N-[2-(4-Methylphenyl)ethyl]-N'-[2-(5-bromopyridyl)]thiourea as a potent inhibitor of NNRTI-resistant and multidrug-resistant human immunodeficiency virus type 1
文献作者:Uckun,F.M.; Mao,C.; Pendergrass,S.; Maher,D.; Zhu,D.; Tuel-Ahlgren,L.; Venkatachalam,T.K.
参考来源:Antivir Chem Chemother 2000,11(2),135