新产品编号:1867269
Chemical Name: N1,N2-Bis(8-quinolinylmethyl)ethane-1,2-diamine tetrahydrochloride
项目整合开发状态: Biological Testing
项目研究机构: Nara Women's University (Originator)
合成路线:Benzylic bromination of 2-methylquinoline (I) by means of N-bromosuccinimide afforded 2-(bromomethyl)quinoline (II).Dimerization of (II) using ethylenediamine gave the corresponding bis(quinolylmethyl)ethylenediamine,which was finally converted to the tetrahydrochloride salt.
合成路线:Benzylic bromination of 8-methylquinoline (I) by means of N-bromosuccinimide afforded 8-(bromomethyl)quinoline (II).Dimerization of (II) using ethylenediamine gave the corresponding bis(quinolylmethyl)ethylenediamine,which was finally converted to the tetrahydrochloride salt.
📌 参考资料/链接:
参考文献标题:Effect of the linking position of a side chain in bis (quinolymethyl)ethylenediamine as a DNA binding agent
文献作者:Mikata,Y.; Onchi,Y.; Kishigami,M.; Yano,S.
参考来源:Chem Pharm Bull 2000,48(4),477