项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Drohynol, IS-35

9,10,11-三甲氧基-5,8,13,13a-四氢-6H-异喹啉并[3,2-a]异喹啉-2,3-二醇 Chemical Name: S-(-)-5,8,13,13a-Tetrahydro-9,10,11-trimethoxy-6H-di- benzo[a,g]quinolizine-2,3-diol hydrochloride
CAS No. 86414-27-9, 86414-28-0...
参考文献标题:Drohynol
文献作者:Markov,M.
参考来源:Drugs Fut 1988,13(8),722

9-Aminocamptothecin, IDEC-132, NSC-603071, NSC-629971((R, S)-isomer), 9-AC

9-氨基喜树碱Chemical Name: (S)-10-Amino-4-ethyl-4-hydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione; 9-Amino-20(S)-camptothecin
CAS No. 91421-43-1
项目整合开发状态: Phas...
参考文献标题:Camptothecin analogs as potent inhibitors of colorectal cancer
文献作者:Wall,M.E.; Wani,M.(Research Triangle Institute)
参考来源:EP 0497910; JP 1993508619; US 5106742; WO 9105556

Rubitecan, 9-Nitrocamptothecin, 9-NC, RFS-2000, Orathecin, Camptogen

9-硝基喜树碱Chemical Name: 9-Nitro-20(S)-camptothecin; 4(S)-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS No. 91421-42-0
项目整合开发状态: Pre-Registered
...
参考文献标题:Synthesis and antitumor activity of 20(S)-camptothecin derivatives: A-ring modified and 7,10-disubstituted camptothecins
文献作者:Matsuoka,S.-I.; Nagata,H.; Furuta,T.; Miyasaka,T.; Yokokura,T.; Sawada,S.; Nokata,K.-I.
参考来源:Chem Pharm Bull 1991,39(12),3183

AVE-0991

AVE 0991钠盐 Chemical Name: N-Ethyl-N'-[3-[4-(5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-ylmethyl)phenyl]-5-isobutylthien-2-ylsulfonyl]urea
CAS No. 304462-19-9, 306288-04-0 (monosodium salt)
项目整合开...
参考文献标题:1-(p-Thienylbenzyl)-imidazoles as angiotensin-(1-7) receptor agonists,method for the production and the utilization thereof and pharmaceutical preparations containing said cpds.
文献作者:Wiemer,G.; Heitsch,H.(Aventis Pharma Deutschland GmbH)
参考来源:EP 1185527; JP 2002544130; US 6235766; US 6429222; WO 0068226

Cycloserine, D-Cycloserine, SC-49088, Seromycin

D-环丝氨酸 L-环丝氨酸 Chemical Name: D-4-Aminoisoxazolidin-3-one; (R)-4-Aminoisoxazolidin-3-one
CAS No. 68-41-7, 339-72-0 ((S)-isomer)
项目整合开发状态: Launched-1952
项目研究机构: Pfizer (Originator), Elan (Not ...
参考文献标题:D-Cycloserine
文献作者:Prous,J.; Mealy,N.; Castar,J.
参考来源:Drugs Fut 1994,19(11),988

K-76 COONa

K76羧酸 Chemical Name: 6-Formyl-3',4',3'a,5',6',7',8',8'a-Octahydro-4,6',7'-trihydroxy-2',5',5',8'a-tetramethylspiro[benzofuran-2(3H),1'(2'H)-naphthalene]-7-carboxylic acid monosodium salt; 6,7-Dihydro...
参考文献标题:K-76 COONa
文献作者:Serradell,M.N.; Castar,J.; Hillier,K.
参考来源:Drugs Fut 1984,9(7),514

BMS-345541

N-(1,8-二甲基咪唑并[1,2-a]喹喔啉-4-基)-1,2-乙二胺 Chemical Name: N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine hydrochloride
CAS No. 445430-59-1, 445430-58-0 (free base)
项目整合开发状态: Preclini...
参考文献标题:Methods of treating inflammatory and immune diseases using inhibitors of IkappaB kinase (IKK)
文献作者:Zusi,F.C.; Burke,J.R.; Townsend,R.M.; Qiu,Y.; Nadler,S.(Bristol-Myers Squibb Co.)
参考来源:EP 1363993; US 2002072523; WO 0260386

Lidofenin, 99Tcm-HIDA, Hepato-Scan

N-(2,6-二甲基苯基氨基甲酰甲基)亚氨基二乙酸Chemical Name: [N-(2,6-Dimethylphenyl)carbamoylmethylimino]diacetic acid technetium-99
CAS No. 59160-29-1
项目整合开发状态: Not Determined
项目研究机构:
合成路线:Compound can be p...
参考文献标题:Tissue distribution of technetium-99m and carbon-14 labeled N-(2,6-dimethylphenylcarbamoylmethyl)iminodiacetic acid
文献作者:Callery,P.S.; Faith,W.C.; Loberg,M.D.; Fields,A.T.; Harvey,E.B.; Cooper,M.D.
参考来源:J Med Chem 1976,19(7),962-964

Sutent, SU-011248, SU-11248

N-(2-二乙胺基乙基)-5-(5-氟-2-氧代-1,2-二氢吲哚-3-基亚甲基)-2,4-二甲基-1H-吡咯-3-甲酰胺 Chemical Name: (Z)-N-[2-(Diethylamino)ethyl]-5-(5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamid...
参考文献标题:Pyrrole substd.2-indolinone protein kinase inhibitors
文献作者:Wei,C.C.; Miller,T.; Tang,P.C.; Nematalla,A.S.; Li,X.; Liang,C.; Shirazian,S.; Su,L.; Vojkovsky,T.(Sugen,Inc.)
参考来源:EP 1255752; US 2002156292; US 6573293; WO 0160814

Diacetolol hydrochloride, M&B-16942A, EU-4891

N-(3-乙酰基-4-(2-羟基-3-(异丙基氨基)丙氧基)苯基)乙酰胺 Chemical Name: N-[3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide hydrochloride
CAS No. 69796-04-9, 22568-64-5 (free base)
项目整合开发状态: Biolog...
参考文献标题:Diacetolol hydrochloride
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Weetman,D.F.
参考来源:Drugs Fut 1981,6(8),467