BMS-345541

N-(1,8-二甲基咪唑并[1,2-a]喹喔啉-4-基)-1,2-乙二胺 Chemical Name: N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine hydrochloride
CAS No. 445430-59-1, 445430-58-0 (free base)
项目整合开发状态: Preclinical
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Decarboxylation of the tricyclic carboxylic acid (I) in boiling diphenyl ether leads to (II).This is further chlorinated to (III) employing POCl3 in the presence of N,N-diethylaniline.Then,displacement of chloride (III) with ethylenediamine at 60癈 gives rise to the title compound,which is finally isolated as the corresponding hydrochloride salt.