Drohynol, IS-35
9,10,11-三甲氧基-5,8,13,13a-四氢-6H-异喹啉并[3,2-a]异喹啉-2,3-二醇 Chemical Name: S-(-)-5,8,13,13a-Tetrahydro-9,10,11-trimethoxy-6H-di- benzo[a,g]quinolizine-2,3-diol hydrochloride
CAS No. 86414-27-9, 86414-28-0 (free base)
项目整合开发状态: Clinical
项目研究机构: Med. Acad. Sofia (Originator)
合成路线:Title compound is obtained by Mannich reaction after treatment of S-(-)-1-(3,4,5-trimethoxybenzyl)-6,7-dihydroxy-1.2,3,4-tetrahydroisoquinoline hydrochloride (I) with paraformaldehyde using ethanol and catalytic amounts of hydrochloric acid.
📌 参考资料/链接：
参考文献标题:Drohynol
文献作者:Markov,M.
参考来源:Drugs Fut 1988,13(8),722
📄 详细内容
合成路线:Title compound is obtained by Mannich reaction after treatment of S-(-)-1-(3,4,5-trimethoxybenzyl)-6,7-dihydroxy-1.2,3,4-tetrahydroisoquinoline hydrochloride (I) with paraformaldehyde using ethanol and catalytic amounts of hydrochloric acid.
参考文献标题:Hexahydrodibenzo[a,f]quinolizine and method for their synthesis
文献作者:Ivanov,Ch.; Vankov,S.; Nikolova,M.; Zhelyazkov,D.; Ivanova,N.; Markov,M.; Tanev,G.; Florin,A.; Ilieva,A.
参考来源:License 32353,INRA S.1982,
产品链接: CAS No.86414-28-0››