合成路线:The acetylation of 4-acetamidophenol (I) with acetyl chloride in refluxing benzene gives 4-acetoxyacetanilide (II),which by a Fries reaction with AlCl3 at 170 C is converted into 2-hydroxy-5-acetamidoacetophenone (III).(1,2) The reaction of (III) with epichlorohydrin (IV) by means of sodium ethoxide in refluxing ethanol affords 1-(2-acetyl-4-acetamidophenoxy)-2,3-epoxypropane (V),which is finally treated with isopropylamine (VI) in refluxing ethanol.(1-3)
参考文献标题:New series of cardioselective adrenergic beta-receptor blocking compounds.1-(2-Acyl-4-acylaminophenoxy)3-isopropylaminopropan-2-ols
文献作者:Basil,B.; et al.
参考来源:J Med Chem 1976,19(3),399
合成路线:The acetylation of 4-acetamidophenol (I) with acetyl chloride in refluxing benzene gives 4-acetoxyacetanilide (II),which by a Fries reaction with AlCl3 at 170 C is converted into 2-hydroxy-5-acetamidoacetophenone (III).(1,2) The reaction of (III) with epichlorohydrin (IV) by means of sodium ethoxide in refluxing ethanol affords 1-(2-acetyl-4-acetamidophenoxy)-2,3-epoxypropane (V),which is finally treated with isopropylamine (VI) in refluxing ethanol.(1-3)
参考文献标题:
文献作者:Woolbridge,K.R.H.; Basil,B.(May & Baker,Ltd.)
参考来源:BE 715205; CA 834734; CH 485663; CH 489467; FR 1570087; FR M7616; GB 1231783; GB 681537; JP 7134414; NL 6806946; ZA 6803130
合成路线:The acetylation of 4-acetamidophenol (I) with acetyl chloride in refluxing benzene gives 4-acetoxyacetanilide (II),which by a Fries reaction with AlCl3 at 170 C is converted into 2-hydroxy-5-acetamidoacetophenone (III).(1,2) The reaction of (III) with epichlorohydrin (IV) by means of sodium ethoxide in refluxing ethanol affords 1-(2-acetyl-4-acetamidophenoxy)-2,3-epoxypropane (V),which is finally treated with isopropylamine (VI) in refluxing ethanol.(1-3)
参考文献标题:
文献作者:Woolbridge,K.R.H.; Basil,B.(May & Baker,Ltd.)
参考来源:ZA 6808345
产品链接: CAS No. 69796-04-9›› 产品链接: CAS No.22568-64-5››