Lidofenin, 99Tcm-HIDA, Hepato-Scan
N-(2,6-二甲基苯基氨基甲酰甲基)亚氨基二乙酸Chemical Name: [N-(2,6-Dimethylphenyl)carbamoylmethylimino]diacetic acid technetium-99
CAS No. 59160-29-1
项目整合开发状态: Not Determined
项目研究机构:
合成路线:Compound can be prepared in two related ways:1) The acylation of 2,6-dimethylaniline (I) with chloroacetyl chloride (II) in acetic acid gives omega-chloro-2,6-dimethylacetanilide (III),which is then condensed with disodium salt of iminodiacetic acid (IV) in refluxing ethanol-water.2) The reaction of (III) with ammonia in ethanol gives omega-amino-2,6-dimethylacetanilide (V),which is finally treated with chloroacetic acid (A) and NaOH in refluxing 95% ethanol.
📌 参考资料/链接：
参考文献标题:Tissue distribution of technetium-99m and carbon-14 labeled N-(2,6-dimethylphenylcarbamoylmethyl)iminodiacetic acid
文献作者:Callery,P.S.; Faith,W.C.; Loberg,M.D.; Fields,A.T.; Harvey,E.B.; Cooper,M.D.
参考来源:J Med Chem 1976,19(7),962-964
📄 详细内容
合成路线:Compound can be prepared in two related ways:1) The acylation of 2,6-dimethylaniline (I) with chloroacetyl chloride (II) in acetic acid gives omega-chloro-2,6-dimethylacetanilide (III),which is then condensed with disodium salt of iminodiacetic acid (IV) in refluxing ethanol-water.2) The reaction of (III) with ammonia in ethanol gives omega-amino-2,6-dimethylacetanilide (V),which is finally treated with chloroacetic acid (A) and NaOH in refluxing 95% ethanol.
参考文献标题:Lidofenin
文献作者:Castar,J.; Blancafort,P.; Serradell,M.N.; Paton,D.M.
参考来源:Drugs Fut 1979,4(5),342
产品链接: CAS No. 59160-29-1››