K-76 COONa
K76羧酸 Chemical Name: 6-Formyl-3',4',3'a,5',6',7',8',8'a-Octahydro-4,6',7'-trihydroxy-2',5',5',8'a-tetramethylspiro[benzofuran-2(3H),1'(2'H)-naphthalene]-7-carboxylic acid monosodium salt; 6,7-Dihydroxy-2,5,5,8a-tetramethyl-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalene-1-spiro-2'-(7'-carboxy-6'-formyl-4'-hydroxy-2',3'-dihydrobenzofuran) monosodium salt
CAS No. 70016-72-7 (diNa salt), 71117-22-1 (free acid)
项目整合开发状态: Preclinical
项目研究机构: Otsuka (Originator)
合成路线:By oxidation of K-76 (I) with Ag2O in water (I) is obtained from a culture broth of Stachybotrys complementi.
📌 参考资料/链接：
参考文献标题:K-76 COONa
文献作者:Serradell,M.N.; Castar,J.; Hillier,K.
参考来源:Drugs Fut 1984,9(7),514
📄 详细内容
合成路线:By oxidation of K-76 (I) with Ag2O in water (I) is obtained from a culture broth of Stachybotrys complementi.
参考文献标题:A complement inhibitor produced by Stachybotrys complementi,nov.sp.K-76,a new sepecies of Fungi imperfecti
文献作者:Miyazaki,W.; Tamaoka,H.; Shinohara,M.; Kaise,H.; Izawa,T.; Nakano,Y.; Kinoshita,T.; Hong,K.; Inoue,K.
参考来源:Microbiol Immunol 1980,24(11),1091
合成路线:By oxidation of K-76 (I) with Ag2O in water (I) is obtained from a culture broth of Stachybotrys complementi.
参考文献标题:Composition for prophylaxis and therapy of hepatitis
文献作者:Shinohara,M.; Kaise,H.; Nakano,Y.; Izawa,T.; Oshiro,Y.; Miyazaki,W.
参考来源:DE 3031788; IT 1207133; JP 56030917; US 4831053
合成路线:By oxidation of K-76 (I) with Ag2O in water (I) is obtained from a culture broth of Stachybotrys complementi.
参考文献标题:An anticomplementary agent,K-76 monocarboxylic acid: Its site and mechanism of inhibition of the complement activation cascade
文献作者:Hong,K.; et al.
参考来源:J Immunol 1979,1222418-23
产品链接: CAS No.71117-22-1››