项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

QAB-205, NVP-QAB-205, NVP-QAB-205-AA

Chemical Name: N-[4-[6-(Cyclobutylamino)-9H-purin-2-ylamino]phenyl]-N-methylacetamide
CAS No. 325165-07-9 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator)
合成路线:2,6-Dichl...
参考文献标题:Purine derivs.inhibitors of tyrosine protein kinase syk
文献作者:Menear,K.A.; Mattes,H.; Collingwood,S.P.; Walker,C.V.; Hayler,J.; Le Grand,D.M.; Cockcroft,X.-L.(Novartis AG; Novartis-Erfindungen VmbH)
参考来源:EP 1200435; WO 0109134

RPR-202868

Chemical Name: 5-[(2S)-1,2,3,6-Tetrahydro-5-(4-morpholinylmethyl)-2-pyridinecarboxylic acid]pristinamycin IA ; N-(3-Hydroxypyridin-2-ylcarbonyl)-L-threonyl-D-(2-aminobutyryl)-L-prolyl-L-N-methyl-[4-(N...
参考文献标题:Streptogramin derivs.,production thereof and compsns.containing the same
文献作者:Barriere,J.-C.; Pantel,G.; Bacqu? E.; Doerflinger,G.; Dutruc-Rosset,G.(Aventis Pharma SA)
参考来源:EP 1204675; FR 2796949; US 6541451; WO 0110895

新产品编号:758287

Chemical Name: Cyclo[D-alanyl-L-tyrosyl-L-valyl-4(R)-hydroxy-L-prolyl-D-allothreonyl-L-threonyl-3(S)-hydroxy-L-prolyl-3(R)-hydroxy-L-glutaminylglycyl-D-allothreonyl-L-ornithyl-3(S)-aminohexadecanoyl-D...
参考文献标题:An expedient synthesis of the amide analog of the potent antifungal lipopeptidolactone FR901469
文献作者:Hashimoto,S.; Hashimoto,M.; Tanaka,A.; Fujie,A.; Shigematsu,N.; Barrett,D.
参考来源:Tetrahedron Lett 2001,42(4),703

A-192558

Chemical Name: (?-4(R*)-Amino-1-(N-ethyl-N-isopropylcarbamoyl)-5(S*)-(trifluoroacetamidomethyl)pyrrolidine-3(R*)-carboxylic acid
CAS No. 341969-96-8 (enantiomer)
项目整合开发状态: Biological Testing
...
参考文献标题:Design,synthesis,and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores
文献作者:Wang,G.T.; Chen,Y.; Wang,S.; Gentles,R.; Sowin,T.; Kati,W.; Muchmore,S.; Giranda,V.; Stewart,K.; Sham,H.; Kempf,D.; Laver,W.G.
参考来源:J Med Chem 2001,44(8),1192

新产品编号:832641

Chemical Name: [2(1)-Decyl-3,3,7,8,12,13,17,18-octaethyl-3H-benzo[at]porphyrinato(2-)]zinc; (SP-4-2)-[20-Decyl-5,6,10,11,15,16,22,22-octaethyl-4,7:14,17-diimino-2,21-methano-9,12-nitrilo-12H-1-benzacy...
参考文献标题:A simple and efficient approach for the synthesis of fluorinated and nonfluorinated octaethylporphyrin-based benzochlorins with variable lipophilicity.Their in vivo tumor uptake,and the preliminary in vitro photosensitizing
文献作者:Li,G.; Graham,A.; Potter,W.; Grossman,Z.D.; Oseroff,A.; Dougherty,T.J.; Pandey,R.K.
参考来源:J Org Chem 2001,66(4),1316

RPR-203494

Chemical Name: trans-N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-[5-methyl-5-(4-morpholinylcarbonyl)-1,3-dioxan-2-yl]-1H-imidazol-5-yl]pyrimidin-2-amine
CAS No. 218160-26-0
项目整合开发状态: Preclinical
项目...
参考文献标题:Imidazolyl-cyclic acetals
文献作者:Halley,F.; Porter,B.; Bamborough,P.L.; Lewis,R.A.; Ratcliffe,A.J.; Wallace,P.A.; McLay,I.M.; McKenna,J.M.; Lythgoe,D.J.; Collis,A.J.(Rh鬾e-Poulenc Rorer Ltd.)
参考来源:EP 0988301; WO 9856788

新产品编号:187185

Chemical Name: (4S,5R,6R)-4-Amino-6-[N-(2-phenylethyl)-N-propylcarbamoyl]-5-(trifluoroacetamido)-5,6-dihydro-4H-pyran-2-carboxylic acid
CAS No. 185381-95-7
项目整合开发状态: Preclinical
项目研究机构: Biota...
参考文献标题:6-Carboxamido dihydropyran derivs.
文献作者:Smith,P.; Sollis,S.; Cherry,P.; Howes,P.(Biota Scientific Management Pty Ltd.)
参考来源:US 5990156; WO 9636628

2'-Palmitoylpaclitaxel, C16HTD

Chemical Name: 3(S)-Benzamido-2(R)-(hexadecanoyloxy)benzenepropionic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6...
参考文献标题:Hydrolyzable hydrophobic taxanes: Synthesis and anti-cancer activities
文献作者:Ali,S.; Ahmad,I.; Peters,A.; Masters,G.; Minchey,S.; Janoff,A.; Mayhew,E.
参考来源:Anti-Cancer Drugs 2001,12(2),117

(-)-2-(2-Bromohexadecanoyl)paclitaxel, BrC16HT, (-)-BRT-216

Chemical Name: (-)-3(S)-Benzamido-2(R)-(2-bromohexadecanoyloxy)benzenepropionic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a...
参考文献标题:Hydrolysis-promoting hydrophobic taxane derivs.
文献作者:Mayhew,E.; Janoff,A.S.; Bhattacharya,S.; Kehane,G.; Ahmad,I.; Franklin,J.C.; Ali,S.(The Liposome Company,Ltd.)
参考来源:US 6107332

A-358

Chemical Name: N,N'-(4-Chloro-1,2-phenylene)bis[4-(trifluoromethoxy)benzenesulfonamide]
CAS No. 335335-69-8
项目整合开发状态: Preclinical
项目研究机构: Arrow Therapeutics (Originator)
合成路线:The acylation...
参考文献标题:Enzyme inhibitors
文献作者:Madge,D.; Wishart,G.; Dolman,M.; Maunder,P.(Arrow Therapeutics Ltd.)
参考来源:WO 0128537