项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:669695

Chemical Name: 2-(4'-Cyanobiphenyl-4-yloxymethyl)-4-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)butyrohydroxamic acid
CAS No. 253442-03-4
项目整合开发状态: Preclinical
项目研究机构: Servier (Originator)
...
参考文献标题:Carboxylic and hydroxamic acid cpds.inhibiting metalloproteases,method for preparing same and pharmaceutical compsns.containing them
文献作者:Guilbaud,N.; Atassi,G.; Le Diguarher,T.; Bonnet,J.; Sabatini,M.; Casara,P.; Chollet,A.-M.; Pierre,A.; Tucker,G.(ADIR et Cie.)
参考来源:EP 1091937; FR 2780402; WO 0000473

APC-0576

Chemical Name: N-[6-[4-[(1S)-2,2-Dimethylcyclopropylcarboxamido]phenoxy]pyridin-3-yl]-2,2-dimethylcyclopropane-1(S)-carboxamide
CAS No. 318967-58-7, 318967-56-5 (diastereomer), 318967-59-8 (diaster...
参考文献标题:Heterocyclic cpds.and medicinal use thereof
文献作者:Yamamoto,T.; Iino,Y.; Kobayashi,T.; Fujita,K.; Hatanaka,T.; Kodaira,A.; Takehana,K.; Konishi,A.(Ajinomoto Co.,Inc.)
参考来源:EP 1193255; WO 0102359

SR-7

Chemical Name: 5-(2-Furylmethoxy)spiro[1,4-dihydronaphthalene-1(4H),2'-naphtho[1,8-de][1,3]dioxin]-4-one
CAS No. 328005-67-0
项目整合开发状态: Biological Testing
项目研究机构: University of Pittsburgh (Ori...
参考文献标题:Synthesis and biological evaluation of deoxypreussomerin A and palmarumycin CP1 and related naphthoquinone spiroketals
文献作者:Wipf,P.; et al.
参考来源:Tetrahedron 2001,57(2),283

ER-112022

Chemical Name: Bis[(5Z,5'Z)-5-Dodecenoic acid] (1R,32R)-6,27-bis(3-oxotetradecanamido)-1,32-diheptyl-9,24-dihydroxy-9,24-dioxido-14,19-dioxo-4,8,10,23,25,29-hexaoxa-13,20-diaza-9,24-diphosphadotriacon...
参考文献标题:Immunological adjuvant cpd.
文献作者:Rossignol,D.P.; Ishizaka,S.T.; Nault,A.; Lewis,M.; Rose,J.; McGuiness,P.; Hawkins,L.D.(Eisai Co.,Ltd.)
参考来源:EP 1147117; US 6290973; WO 0044758

新产品编号:856371

Chemical Name: 5,7-Dihydroxy-8-(3-methyl-2-butenyl)-2-phenyl-4H-1-benzopyran-4-one
CAS No. 34125-75-2
项目整合开发状态: Preclinical
项目研究机构: INSERM (Originator), Universit?Claude Bernard Lyon 1 (Origi...
参考文献标题:C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance
文献作者:Comte,G.; Daskiewicz,J.-B.; Bayet,C.; Conseil,G.; Viornery-Vanier,A.; Dmontet,C.; Di Pietro,A.; Barron,D.
参考来源:J Med Chem 2001,44(5),763

新产品编号:831059

Chemical Name: 4-(2,4-Dichlorophenylamino)-6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-3-carbonitrile
CAS No. 331662-69-2
项目整合开发状态: Biological Testing
项目研究机构: Wyeth Pharmaceuticals (Origi...
参考文献标题:Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles
文献作者:Boschelli,D.H.; Wang,Y.D.; Ye,F.; Wu,B.; Zhang,N.; Dutia,M.; Powell,D.W.; Wissner,A.; Arndt,K.; Weber,J.M.; Boschelli,F.
参考来源:J Med Chem 2001,44(5),822

MG-2121

Chemical Name: 1-Benzothien-2-ylsulfonamidomethylphosphonic acid 2-fluoro-4-nitrophenyl monoester
CAS No. 318460-01-4
项目整合开发状态: Preclinical
项目研究机构: MethylGene (Originator)
合成路线:The condens...
参考文献标题:Propenylamines,pharmaceutical compositions containing them and their use as pharmaceuticals
文献作者:Stz,A.(Novartis AG)
参考来源:EP 0024587; JP 56032440; JP 63313753; Us 4755534

MG-2204

Chemical Name: 4,7-Dichloro-1-benzothien-2-ylsulfonamidomethylphosphonic acid 4-nitrophenyl monoester
CAS No. 318460-47-8, 318463-05-7 (NH3 salt)
项目整合开发状态: Preclinical
项目研究机构: MethylGene (Ori...
参考文献标题:Sulfonamidomethyl phosphonate inhibitors of beta-lactamase
文献作者:Delorme,D.; Besterman,J.M.; Rahil,J.(MethylGene Inc.)
参考来源:EP 1194436; WO 0102411

NR58.4

Chemical Name: N-[2,6-Dioxopiperidin-3(S)-yl]-10-undecenamide
CAS No. 284495-31-4
项目整合开发状态: Preclinical
项目研究机构: NeoRx (Originator)
合成路线:The title compound was prepared by two related proce...
参考文献标题:Cpds.and methods to inhibit or augment an inflammatory response
文献作者:Grainger,D.J.; Tatalick,L.M.(NeoRx Corp.)
参考来源:WO 0042071

新产品编号:182439

Chemical Name: 1-[1-[5-[3,5-Bis(trifluoromethyl)benzyloxy]-3-(3,4-dichlorophenyl)-4(Z)-(methoxyimino)pentyl]piperidin-4-yl]pyrrolidin-2-one
CAS No. 184967-93-9 (undefined isomer)
项目整合开发状态: Biolo...
参考文献标题:Substd.oximes,hydrazones and olefins useful as neurokinin antagonists
文献作者:Shankar,B.B.(Schering Corp.)
参考来源:EP 0823896; EP 0937064; JP 1998506923; JP 2000504341; US 5688960; US 5696267; WO 9634857; WO 9818785