APC-0576

Chemical Name: N-[6-[4-[(1S)-2,2-Dimethylcyclopropylcarboxamido]phenoxy]pyridin-3-yl]-2,2-dimethylcyclopropane-1(S)-carboxamide
CAS No. 318967-58-7, 318967-56-5 (diastereomer), 318967-59-8 (diastereomer), 318967-57-6 (enantiomer), 318967-14-5 (undefined stereoch.)
项目整合开发状态: Preclinical
项目研究机构: Ajinomoto (Originator)
合成路线:Coupling between 2-chloro-5-nitropyridine (I) and 4-nitrophenol (II) affords the diaryl ether (III).Subsequent catalytic hydrogenation of both nitro groups of (III) gives rise to diamine (IV).This is finally acylated with (S)-2,2-dimethylcyclopropanecarbonyl chloride (V) to furnish the title diamide.