2'-Palmitoylpaclitaxel, C16HTD

Chemical Name: 3(S)-Benzamido-2(R)-(hexadecanoyloxy)benzenepropionic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benz[1,2-b]oxet-9-yl ester; [2aR-[2aalpha,4beta,4abeta,6beta,9alpha(2R,3S),11beta,12alpha,12aalpha,12balpha]]-6,12b-Diacetoxy-9-[3-benzamido-2-(hexadecanoyloxy)-3-phenylpropionyloxy]-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benz[1,2-b]oxet- 5-one
CAS No. 343770-65-0
项目整合开发状态: Preclinical
项目研究机构: Elan (Originator)
合成路线:The target compound is obtained by esterification of Taxol (paclitaxel) (I) with hexadecanoic anhydride (II) by means of DCC in dichloromethane.

合成路线:Esterification of Taxol (paclitaxel) (I) with 2-bromohexadecanoic acid (II) by means of DCC in dichloromethane yields the target 2'-(2-bromohexadecanoyl)paclitaxel.