QAB-205, NVP-QAB-205, NVP-QAB-205-AA
Chemical Name: N-[4-[6-(Cyclobutylamino)-9H-purin-2-ylamino]phenyl]-N-methylacetamide
CAS No. 325165-07-9 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator)
合成路线:2,6-Dichloropurine (I) is condensed with cyclobutylamine (II) in the presence of diisopropylethylamine in hot butanol to produce the 6-cyclobutylamino purine (III).The 2-chloro group of purine (III) is then displaced with 4-amino-N-methylacetanilide (IV) in N-methylpyrrolidone at 145 C to furnish the target diamino purine derivative.
📌 参考资料/链接：
参考文献标题:Purine derivs.inhibitors of tyrosine protein kinase syk
文献作者:Menear,K.A.; Mattes,H.; Collingwood,S.P.; Walker,C.V.; Hayler,J.; Le Grand,D.M.; Cockcroft,X.-L.(Novartis AG; Novartis-Erfindungen VmbH)
参考来源:EP 1200435; WO 0109134
📄 详细内容
合成路线:2,6-Dichloropurine (I) is condensed with cyclobutylamine (II) in the presence of diisopropylethylamine in hot butanol to produce the 6-cyclobutylamino purine (III).The 2-chloro group of purine (III) is then displaced with 4-amino-N-methylacetanilide (IV) in N-methylpyrrolidone at 145 C to furnish the target diamino purine derivative.
参考文献标题:Novel 2,6-disubstituted purines - The synthesis of potent and selective inhibitors of the protein tyrosine kinase Syk
文献作者:Bammerlin,H.; Le Grand,D.; Hayler,J.; et al.
参考来源:Drugs Fut 2002,27(Suppl.A),
产品链接: CAS No. 325165-07-9››