A-358
Chemical Name: N,N'-(4-Chloro-1,2-phenylene)bis[4-(trifluoromethoxy)benzenesulfonamide]
CAS No. 335335-69-8
项目整合开发状态: Preclinical
项目研究机构: Arrow Therapeutics (Originator)
合成路线:The acylation of 4-chlorobenzene-1,2-diamine (I) with 4-(trifluoromethoxy)benzenesulfonyl chloride (II) by means of pyridine in acetonitrile gives the target bis sulfonamide.
📌 参考资料/链接：
参考文献标题:Enzyme inhibitors
文献作者:Madge,D.; Wishart,G.; Dolman,M.; Maunder,P.(Arrow Therapeutics Ltd.)
参考来源:WO 0128537
📄 详细内容
合成路线:The acylation of 4-chlorobenzene-1,2-diamine (I) with 4-(trifluoromethoxy)benzenesulfonyl chloride (II) by means of pyridine in acetonitrile gives the target bis sulfonamide.
参考文献标题:Synthesis and SAR of novel inhibitors of the shikimate pathway enzyme dehydroquinate synthase
文献作者:Cockerill,S.; Chapman,S.; Chana,S.; et al.
参考来源:41st Intersci Conf Antimicrob Agents Chemother (Dec 16 2001,Chicago) 2001,Abst F-1693