项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Miltefosine, Hexadecylphosphocholine, HDPC, D-18506, Impavido, Miltex

米替福新Chemical Name: 2-[Hexadecyloxy(hydroxy)phosphoryloxy]-N,N,N-trimethylethanaminium hydroxide inner salt; Choline hydroxide,hexadecyl hydrogen phosphate,inner salt
CAS No. 58066-85-6
项目整合开发状态...
参考文献标题:Hexadecylphosphocholine,a new antineoplastic agent: cytotoxic properties in leukaemic cells
文献作者:Kin,D.J.; Unger,C.; Berger,M.R.; Fleer,E.A.M.; Nagel,G.A.; Eibl,H.
参考来源:J Cancer Res Clin Oncol 1986,11124

Mitratapide, R-103757

米瑞他匹Chemical Name: 4-[4-[4-[4-[(2S,4R)-2-(4-Chlorophenyl)-2-(4-methyl-4H-1,2,4-triazol-3-ylsulfanylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl]piperazin-1-yl]phenyl]-2-[1(R)-methylpropyl]-2,4-dihydro-3H-...
参考文献标题:Structure-activity relationship of a novel chemical family of MTP inhibitors with lipid-lowering properties
文献作者:Backx,L.; Meerpoel,L.; Heeres,J.; et al.
参考来源:16th Int Symp Med Chem (Sept 18 2000,Bologna) 2000,Abst PA-142

Mirfentanil hydrochloride, OHM-10579(free base), ANQ-3508 HCl, A-3508 hydrochloride

米芬太尼 Chemical Name: N-(1-Phenethyl-4-piperidinyl)-N-(2-pyrazinyl)furan-2-carboxamide hydrochloride
CAS No. 119413-53-5, 117523-47-4 (free base), 118142-72-6 (oxalate salt)
项目整合开发状态: Phase II 参考文献标题:New 4-(heteroanilido)-piperidines structurally related to the pure opioid agonist,fentanyl,with agonist and/or antagonist properties
文献作者:Rudo,F.G.; Spender,H.K.; Doorley,B.M.; Wynn,R.L.; Spaulding,T.; Bagley,J.R.
参考来源:J Med Chem 1989,32(3),663-671

ZT-1

米莫派唑Chemical Name: (5R,9R)-5-(5-Chloro-2-hydroxy-3-methoxybenzylideneamino)-11-ethylidene-7-methyl-1,2,5,6,9,10-hexahydro-5,9-methanocycloocta[b]pyridin-2-one
CAS No. 180694-97-7
项目整合开发状态: Phas...
参考文献标题:Huperzine A derivs.,their preparation and their use
文献作者:Zhu,D.; Tang,X.; Li,J.; Zhu,C.; Shen,J.; Wu,G.; Jiang,S.; Yamaguchi,T.; Tanaka,K.; Wakanatsu,T.; Nishimura,H.(Shanghai Institute Materia Medica; Tsumura & Co.)
参考来源:EP 0806416; JP 1998511651; US 5929084; WO 9620176

Minaprine hydrochloride, 30038CM, Agr-1240, Alcas, Cantor

米那卜林盐酸盐 Chemical Name: 3-(2-Morpholinoethylamino)-4-methyl-6-phenylpyridazine dihydrochloride; 4-[2-[(4-Methyl-6-phenyl-3-pyridazinyl)amino]ethyl]morpholine dihydrochloride
CAS No. 25953-17-7, 259...
参考文献标题:Minaprine
文献作者:Castar,J.
参考来源:Drugs Fut 1977,2(12),811

Sobuzoxane, MST-16, Perazolin

索布佐生Chemical Name: 4,4'-Ethane-1,2-diylbis[1-(isobutoxycarbonyloxymethyl)piperazine-2,6-dione]
CAS No. 98631-95-9
项目整合开发状态: Launched-1994
项目研究机构: Shanghai Institute Materia Medica (Originato...
参考文献标题:MST-16
文献作者:Ruyun,J.
参考来源:Drugs Fut 1986,11(4),267

Viqualine hydrochloride, PK-5078

维喹啉 Chemical Name: 6-Methoxy-4-[3-[(3R,4R)-3-vinyl-4-piperidyl]propyl]quinoline; 4-(R)-[3-(6-Methoxy-4-quinolyl)propyl]-3(R)-vinylpiperidine; (3R-cis)-4-[3-(3-Ethenyl-4-piperidinyl)propyl]-6-methoxyq...
参考文献标题:Viqualine
文献作者:Castar,J.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1983,8(6),521

Rocastine fumarate, AHR-11325

罗卡斯汀罗卡斯汀Chemical Name: 2-[2-(Dimethylaminoethyl)-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione (E)-2-butenedioate
CAS No. 91833-50-0, 91833-49-7 (free base), 91833-77-1 (free base,...
参考文献标题:Fused aromatic oxazepinones and sulphur analogues thereof and their preparation and use in counteracting histamine
文献作者:Cale,A.D.Jr.; Franko,B.V.; Leonard,C.A.(A.H.Robins Co.Inc.)
参考来源:EP 0107930; ES 8607956; ES 8802574; US 4592866; US 4604388

FK-228, NSC-630176, FR-901228

罗米地辛Chemical Name: (1S,4S,10S,21R)-7-[(Z)-Ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16(E)-ene-3,6,9,19,22-pentone; N-[3(S)-Hydroxy-7-sulfanyl-4(E)-hepteno...
参考文献标题:FR901228
文献作者:Wang,H.-C.R.
参考来源:Drugs Fut 1999,24(11),1184

Roxithromycin, RU-965, RU-28965, Rossitrol, Overall, Assoral, Rulid

罗红霉素Chemical Name: Erythromycin 9-[O-(2-methoxyethoxy)methyloxime]
CAS No. 80214-83-1
项目整合开发状态: Launched-1987
项目研究机构: Aventis Pharma (Originator), Camillo Corvi (Originator), Eisai (Licensee...
参考文献标题:Novel erythromycin a derivatives
文献作者:Gouin,A.S.; Lutz,A.; Gasc,J.-C.(Aventis Pharmaceuticals,Inc.)
参考来源:EP 0033255; FR 2473525; JP 81100799; US 4349545