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项目整合精选>>>Roxithromycin, RU-965, RU-28965, Rossitrol, Overall, Assoral, Rulid
Roxithromycin, RU-965, RU-28965, Rossitrol, Overall, Assoral, Rulid
罗红霉素Chemical Name: Erythromycin 9-[O-(2-methoxyethoxy)methyloxime]
CAS No. 80214-83-1
项目整合开发状态: Launched-1987
项目研究机构: Aventis Pharma (Originator), Camillo Corvi (Originator), Eisai (Licensee)
合成路线:By condensation of erythromycin oxime (II) [obtained from erythromycin (I) and hydroxylamine hydrochloride] with (2 methoxyethoxy)methyl chloride (III) in the presence of NaHCO3 in refluxing acetone.
📌 参考资料/链接：
参考文献标题:Novel erythromycin a derivatives
文献作者:Gouin,A.S.; Lutz,A.; Gasc,J.-C.(Aventis Pharmaceuticals,Inc.)
参考来源:EP 0033255; FR 2473525; JP 81100799; US 4349545
📄 详细内容
合成路线:By condensation of erythromycin oxime (II) [obtained from erythromycin (I) and hydroxylamine hydrochloride] with (2 methoxyethoxy)methyl chloride (III) in the presence of NaHCO3 in refluxing acetone.
参考文献标题:Roxithromycin
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(9),767
合成路线:By condensation of erythromycin oxime (II) [obtained from erythromycin (I) and hydroxylamine hydrochloride] with (2 methoxyethoxy)methyl chloride (III) in the presence of NaHCO3 in refluxing acetone.
参考文献标题:New ether oxime derivatives of erythromycin A: Preparation and antibacterial activities
文献作者:Gouin D'Ambrieres,S.; Chantot,J.F.; Gasc,J.C.; Lutz,A.
参考来源:23rd Intersci Conf Antimicrob Agents Chemother (Oct 24-26,Las Vegas) 1983,Abst 447
产品链接: CAS No. 80214-83-1››