Mirfentanil hydrochloride, OHM-10579(free base), ANQ-3508 HCl, A-3508 hydrochloride
米芬太尼 Chemical Name: N-(1-Phenethyl-4-piperidinyl)-N-(2-pyrazinyl)furan-2-carboxamide hydrochloride
CAS No. 119413-53-5, 117523-47-4 (free base), 118142-72-6 (oxalate salt)
项目整合开发状态: Phase II
项目研究机构: Baxter (Originator)
合成路线:4-Amino-1-phenethylpiperidine (I) is stirred with chloropyrazine (II) and copper powder in phenyl ether at 170-175 C to obtain 1-phenethyl-4-[N-(pyrazinyl)amino]piperidine (III).Subsequent acylation of (III) with 2-furoyl chloride in 1,2-dichloroethane yields mirfentanil as the hydrochloride salt after cooling and filtration.Further purification is achieved by recrystallization from n-propanol.
📌 参考资料/链接：
参考文献标题:New 4-(heteroanilido)-piperidines structurally related to the pure opioid agonist,fentanyl,with agonist and/or antagonist properties
文献作者:Rudo,F.G.; Spender,H.K.; Doorley,B.M.; Wynn,R.L.; Spaulding,T.; Bagley,J.R.
参考来源:J Med Chem 1989,32(3),663-671
📄 详细内容
合成路线:4-Amino-1-phenethylpiperidine (I) is stirred with chloropyrazine (II) and copper powder in phenyl ether at 170-175 C to obtain 1-phenethyl-4-[N-(pyrazinyl)amino]piperidine (III).Subsequent acylation of (III) with 2-furoyl chloride in 1,2-dichloroethane yields mirfentanil as the hydrochloride salt after cooling and filtration.Further purification is achieved by recrystallization from n-propanol.
参考文献标题:MIRFENTANIL HYDROCHLORIDE
文献作者:Bagley,J.R.; Doorley,B.M.; Ossipov,M.H.; Knight,V.V.; Jerussi,T.P.; Benvenga,M.J.; Wilhelm,J.A.; Waters,S.J.; Spaulding,T.C.; Wynn,R.L.; Rudo,F.G.; Glass,P.S.A.
参考来源:Drugs Fut 1990,15(8),798
产品链接: CAS No. 119413-53-5›› 产品链接: CAS No.117523-47-4››