项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Alfaprostol, Ro-229000, K-11941, Alfavet

阿法前列醇Chemical Name: [1R-[1alpha(Z),2beta(S*),3alpha,5alpha]]-7-[2-(5-Cyclohexyl-3-hydroxy-1-pentynyl)-3,5-dihydroxycyclopentyl]-5-heptenoic acid methyl ester; 7-[(1R,2S,3R,5S)-2-[5-Cyclohexyl-3(S)-hyd...
参考文献标题:Omega-nor-cycloalkyl-13,14-dehydroprostaglandins
文献作者:Gandolfi,C.; Pellegata,R.; Ceserani,R.; Usardi,M.M.(Pharmacia Corp.)
参考来源:DE 2539116; FR 2285866; FR 2378757; GB 1483880; JP 51125044; JP 58135858; US 4035415; US 4361577

Loxistatin, Aloxistatin, E-64-d, EST, Estate

阿洛司他丁Chemical Name: (+)-(2S,3S)-2,3-Epoxy-N-[1(S)-(N-isopentylcarbamoyl)-3-methylbutyl]succinamic acid ethyl ester; (+)-(2S,3S)-3-[3-Methyl-1(S)-[N-(3-methylbutyl)carbamoyl]butylcarbamoyl]oxirane-2-ca...
参考文献标题:Trans-epoxysuccinic acid derivative
文献作者:Soda,K.; et al.(Taisho Pharmaceutical Co.,Ltd.)
参考来源:JP 60174777

Alovudine, MIV-310, CL-184824, FddThd, FLT, 3'F-TdR

阿洛夫定Chemical Name: 3'-Deoxy-3'-fluorothymidine
CAS No. 25526-93-6, 115275-05-3 (monoHCl)
项目整合开发状态: Phase II
项目研究机构: Medivir (Proprietary), Wyeth Pharmaceuticals (Originator), Boehringer Ingel...
参考文献标题:2,3-Dideoxy-3'-fluorothymidine and related cpds.for the treatment of adenovirus infections
文献作者:Selway,J.W.T.; Beacham III,L.M.; Daluge,S.M.; Tuttle,J.V.; Krenitsky,T.A.(Glaxo Wellcome plc)
参考来源:AU 8821429; EP 0305117; EP 0479336; JP 1989068325; US 5070078

Aprepitant, MK-869, MK-0869, L-754030, Emend

阿瑞吡坦阿瑞匹坦杂质 5-[[(2S,3R)-2-[(1R)-1-[3,5-双(三氟甲基)苯乙基]乙氧基]-3-(4-氟苯)吗啡素-4-基]甲基]-1,2-二氢-1,2,4-三唑-3-1Chemical Name: 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylme...
参考文献标题:Morpholine and thiomorpholine tachykinin receptor antagonists
文献作者:Dorn,C.P.; Hale,J.J.; Maccoss,M.; Mills,S.G.; Ladduwahetty,T.; Shah,S.K.(Merck & Co.,Inc.)
参考来源:EP 0577394; JP 1994172178; US 5719147; WO 9400440; WO 9516679

Aripiprazole, OPC-31, OPC-14597, Abilify, Abilitat

阿立哌唑Chemical Name: 7-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydrocarbostyril; 7-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy]-1,2,3,4-tetrahydroquinolin-2-one
CAS No. 129722-12-9...
参考文献标题:Carbostyril derivs
文献作者:Oshiro,Y.; Sato,S.; Kurahashi,N.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:EP 0367141; JP 1990191256; JP 1995304740; JP 1995304741; US 5006528

Alizapride, Limican, Liticum

阿立必利Chemical Name: 5-(1-Allylpyrrolidin-2-ylmethylaminocarbonyl)-6-methoxybenzotriazole
CAS No. 59338-93-1
项目整合开发状态: Launched-1981
项目研究机构: Delagrange (Originator), Sanofi-Aventis (Originator)...
参考文献标题:N-(1'-allypyrrolidinyl-2'-methyl)-2-methoxy-4,5-azimido benzamide and its pharmaceutically acceptable salts
文献作者:Bulteau,G.; Acher,J.; Collignon,C.; Monier,J.-C.(Societe d'Etudes Scientifiques et Industrielles de L'Ile de France)
参考来源:US 4039672

Arildone, Win-38020

阿立酮Chemical Name: 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-heptanedione
CAS No. 56219-57-9
项目整合开发状态: Biological Testing
项目研究机构: Sanofi-Aventis (Originator)
合成路线:Condensation of 2-chloro-...
参考文献标题:Arildone
文献作者:Hopkins,S.J.; Castar,J.
参考来源:Drugs Fut 1978,3(1),12

Amidantel, Bay-d-8815(hydrochloride)

阿米太尔Chemical Name: N-[4-[1-(Dimethylamino)ethylideneamino]phenyl]-2-methoxyacetamide
CAS No. 49745-00-8
项目整合开发状态: Not Determined
项目研究机构:
合成路线:4-[[(1-Dimethylamino)ethylidene]amino]nitrobe...
参考文献标题:Amidantel,a potent anthelmintic from a new chemical class
文献作者:
参考来源:Arzneim-Forsch 1979,29(1),31

Amiflamine, (+)-FLA-336

阿米夫胺Chemical Name: (+)-N-[4-[2(S)-Aminopropyl]-3-methylphenyl]-N,N-dimethylamine L- tartrate
CAS No. 77518-07-1 (free base)
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The interaction of N,...
参考文献标题:N-Desmethyl analogues of (+)-4-dimethylamino-2,a-dimethylphenethylamine.Synthesis and configurational relationships
文献作者:Florvall,L.; Persson,M.-L.
参考来源:Acta Chem Scand 1982,B36141

Amitriptylinoxide

阿米替林 N-氧化物Chemical Name: N-[3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl]-N,N-dimethylamine oxide
CAS No. 4317-14-0
项目整合开发状态: Not Determined
项目研究机构:
合成路线:It can be prepare...
参考文献标题:
文献作者:Pedersen,J.B.
参考来源:GB 991651