合成路线:It can be prepared in two different ways:1) By oxidation of 3-(3-dimethylaminopropylidene)dibenzo[a,d]cyclohepta-1,4-diene (I) with H2O2 in methanol (1-5).2) By reaction of 3-(3-bromopropylidene)dibenzo[a,d]cyclohepta-1,4-diene (II) with dimethylhydroxylamine (III) by means of K2CO3 in refluxing acetone (1-3).
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参考来源:FR M3222
合成路线:It can be prepared in two different ways:1) By oxidation of 3-(3-dimethylaminopropylidene)dibenzo[a,d]cyclohepta-1,4-diene (I) with H2O2 in methanol (1-5).2) By reaction of 3-(3-bromopropylidene)dibenzo[a,d]cyclohepta-1,4-diene (II) with dimethylhydroxylamine (III) by means of K2CO3 in refluxing acetone (1-3).
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参考来源:DE 1243180
合成路线:It can be prepared in two different ways:1) By oxidation of 3-(3-dimethylaminopropylidene)dibenzo[a,d]cyclohepta-1,4-diene (I) with H2O2 in methanol (1-5).2) By reaction of 3-(3-bromopropylidene)dibenzo[a,d]cyclohepta-1,4-diene (II) with dimethylhydroxylamine (III) by means of K2CO3 in refluxing acetone (1-3).
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参考来源:DE 1543224; FR 1447508; FR M4832; GB 1095786; NL 6511947
合成路线:It can be prepared in two different ways:1) By oxidation of 3-(3-dimethylaminopropylidene)dibenzo[a,d]cyclohepta-1,4-diene (I) with H2O2 in methanol (1-5).2) By reaction of 3-(3-bromopropylidene)dibenzo[a,d]cyclohepta-1,4-diene (II) with dimethylhydroxylamine (III) by means of K2CO3 in refluxing acetone (1-3).
参考文献标题:Urinary excretion of amitriptyline N-oxide in humans
文献作者:Santagostino,G.; et al.
参考来源:J Pharm Sci 1974,631690
合成路线:It can be prepared in two different ways:1) By oxidation of 3-(3-dimethylaminopropylidene)dibenzo[a,d]cyclohepta-1,4-diene (I) with H2O2 in methanol (1-5).2) By reaction of 3-(3-bromopropylidene)dibenzo[a,d]cyclohepta-1,4-diene (II) with dimethylhydroxylamine (III) by means of K2CO3 in refluxing acetone (1-3).
参考文献标题:Amitriptylinoxide
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Aboul-Enein,H.Y.
参考来源:Drugs Fut 1980,5(5),329
产品链接: CAS No. 4317-14-0››