项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

SPD-754, (-)-BCH-10652, (-)-dOTC, BCH-10618

阿普瑞西他滨Chemical Name: (R,R)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-4-yl]cytosine; (-)-2'-Deoxy-3'-oxa-4'-thiocytidine; 4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-dithiolan-4-yl]-2(1H)-pyrimidinone
CAS No...
参考文献标题:Substd.1,3-oxathiolanes with antiviral properties
文献作者:Mansour,T.S.; Jin,H.(Shire BioChem Inc.)
参考来源:EP 0756595; EP 1153924; JP 1997512526; WO 9529176

Aprosulate sodium, LW-10082

阿普硫钠Chemical Name: Hexadecasodium N,N'-1,3-propanediylbis [2,3,5,6-tetra-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-beta-D-galactopyranosyl)-D-gluconamide]; N,N'-Trimethylenebis[lactobionamide] hexadecakis(so...
参考文献标题:Polysulfuric ester of amides of bis-aldonic acids and their derivs.,process for their preparation and medicine
文献作者:Meinetsberger,E.(Sankyo Pharma GmbH)
参考来源:EP 0312086; US 5008247

Arprinocid, MK-302, Arpocox Pom

阿普西特Chemical Name: 9-(2-Chloro-6-fluorobenzyl)-9H-purin-6-amine
CAS No. 55779-18-5
项目整合开发状态: Not Determined
项目研究机构:
合成路线:This compound can be obtained in two different ways:1) The reactio...
参考文献标题:
文献作者:Vander Zwan,M.C.; et al.
参考来源:BE 863570; DE 2804723; FR 2379536; JP 78124294; NL 7800896; US 4098787; US 4100159; US 4127721; ZA 7800711

Arteflene, Ro-42-1611

阿替夫林Chemical Name: (1S,4R,5R,8S)-4-[(Z)-2,4-Bis(trifluoromethyl)styryl]-4,8-dimethyl-2,3-dioxabicyclo[3.3.1]nonan-7-one
CAS No. 123407-36-3, 123318-27-4 (undefined stereoch.)
项目整合开发状态: Phase II<...
参考文献标题:Bicyclic peroxide
文献作者:Hofheinz,W.; Schmid,G.; Stohler,H.(F.Hoffmann-La Roche AG)
参考来源:AU 8823596; EP 0311955; JP 1989132578; US 4977184

Atenolol, ICI-66082, Blokium, Tenormin

阿替洛尔Chemical Name: 2-[4-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide
CAS No. 29122-68-7
项目整合开发状态: Launched-1975
项目研究机构: Pfizer (Proprietary), AstraZeneca (Originator), Almirall Prode...
参考文献标题:A synthesis of atenolol using a nitrile hydration catalyst
文献作者:Akisanya,J.; et al.
参考来源:Org Process Res Dev 1998,2(4),274

Atipamezole, MPV-1248, Antisedan

阿替美唑Chemical Name: 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)imidazole; 4-(2-Ethylindan-2-yl)-1H-imidazole; 4(5)-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)imidazole
CAS No. 104054-27-5
项目整合开发状态: Phase I
...
参考文献标题:Substd.imidazole derivs.and their preparation and use
文献作者:Karjalainen,A.J.; Virtanen,R.E.; Kurkela,K.O.A.; Karjalainen,A.(Orion Pharma)
参考来源:AU 8550083; EP 0183492; EP 0310745; ES 8704462; ES 8801248; GB 2167408; JP 1986143366

Atiprimod hydrochloride, SK&F-106615-I2(dimaleate), SK&F-106615-A2

阿替莫德Chemical Name: 2-[3-(Diethylamino)propyl]-8,8-dipropyl-2-azaspiro[4.5]decane dihydrochloride; N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride
CAS No. 130065-61-1, 1...
参考文献标题:Immunomodulatory azaspiranes
文献作者:Badger,A.M.; Dimartino,M.J.; Mirabelli,C.K.; Cheeseman,E.N.; Dorman,J.W.; Picker,D.H.; Schwartz,D.A.(SmithKline Beecham plc)
参考来源:AU 8825333; EP 0310321; JP 1991500290; US 4963557; WO 8902889

Azastene, Win-17625

阿查斯顿Chemical Name: 4,4,17-Trimethylandrosta-2,5-dieno[2,3-d]isoxazol--17beta-ol
CAS No. 13074-00-5
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of 4,4,17-trimethyl-17beta-hydroxy-5-...
参考文献标题:
文献作者:Clinton,R.O.; Manson,A.J.
参考来源:US 3135743

Abiraterone, CB-7598

阿比特龙Chemical Name: 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol
CAS No. 154229-19-3
项目整合开发状态: Phase I
项目研究机构: BTG (Originator), Cougar Biotechnology (Licensee)
合成路线:Treatment of dehydroepiand...
参考文献标题:Novel steroidal inhibitors of human cytochrome P450(17alpha) (17alpha-hydroxylase-C17,20-lyase): Potential agents for the treatment of prostatic cancer
文献作者:Potter,G.A.; Barrie,S.E.; Jarman,M.; Rowlands,M.G.
参考来源:J Med Chem 1995,38(13),2463

Alclometasone dipropionate, Sch-22219, Aclosone, Legederm, Aclovate, Almeta, Vaderm, Modrasone, Delonal

阿氯米松双丙酸酯阿氯米松 Chemical Name: (7alpha,11beta,16alpha)-7-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
CAS No. 66734-13-2, 67452-97-5 (free base)
项目整合开发状态: Launch...
参考文献标题:7alpha-Halogeno-3,20-dioxo-1,4-pregnadienes,methods for their manufacture,their use as anti-inflammatory agents,and pharmaceutical formulations useful therefor
文献作者:Green,M.J.; et al.(Schering Corp.)
参考来源:US 4124707