Aprosulate sodium, LW-10082
阿普硫钠Chemical Name: Hexadecasodium N,N'-1,3-propanediylbis [2,3,5,6-tetra-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-beta-D-galactopyranosyl)-D-gluconamide]; N,N'-Trimethylenebis[lactobionamide] hexadecakis(sodium sulfate) ester
CAS No. 123072-45-7
项目整合开发状态: Phase I
项目研究机构: Sankyo (Originator)
合成路线:One-pot reaction of calcium lactobionate (calcium 4-O-beta-D-galactopyranosyl-D-gluconate) (I) with Lewatit S1010,1,3-diaminopropane (II) in dimethylformamide,SO3-pyridine complex and aqueous sodium hydroxide.
📌 参考资料/链接：
参考文献标题:Polysulfuric ester of amides of bis-aldonic acids and their derivs.,process for their preparation and medicine
文献作者:Meinetsberger,E.(Sankyo Pharma GmbH)
参考来源:EP 0312086; US 5008247
📄 详细内容
合成路线:One-pot reaction of calcium lactobionate (calcium 4-O-beta-D-galactopyranosyl-D-gluconate) (I) with Lewatit S1010,1,3-diaminopropane (II) in dimethylformamide,SO3-pyridine complex and aqueous sodium hydroxide.
参考文献标题:Bis-aldonic acid amide and process for their preparation
文献作者:Meinetsberger,E.(Sankyo Pharma GmbH)
参考来源:EP 0312087; US 5037973
合成路线:One-pot reaction of calcium lactobionate (calcium 4-O-beta-D-galactopyranosyl-D-gluconate) (I) with Lewatit S1010,1,3-diaminopropane (II) in dimethylformamide,SO3-pyridine complex and aqueous sodium hydroxide.
参考文献标题:Aprosulate Sodium
文献作者:Graul,A.; Castar,J.; Prous,J.
参考来源:Drugs Fut 1994,19(8),721
产品链接: CAS No. 123072-45-7››