项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Abanoquil mesilate, UK-52046-27

阿巴诺喹甲磺酸盐 2-(6,7-二甲氧基-3,4-二氢-1H-异喹啉-2-基)-6,7-二甲氧基喹啉-4-胺 Chemical Name: 4-Amino-6,7-dimethoxy-2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)quinoline methanesulfonate
CAS No. 118931-00-3, 90402...
参考文献标题:2-Substd.-4-amino-6,7-dimethoxyquinolines
文献作者:Campbell,S.F.; Hardstone,J.D.(Pfizer Inc.)
参考来源:EP 0100200

Apafant, DE-081, WEB-2086

阿帕泛Chemical Name: 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]propionic acid morpholide
CAS No. 105219-56-5
项目整合开发状态: Discontinued
项目研究机构: Boehring...
参考文献标题:Thieno-triazolo-1,4-diazepino-2-carboxamides,proc
文献作者:Weber,K.-H.; Walther,G.; Harreus,A.; Casals Stenzel,J.; Muacevic,G.; Tr鰃er,W.(Boehringer Ingelheim GmbH)
参考来源:AU 8652728; DE 3502392; EP 0194416; ES 8802426; ES 8802523; JP 1986176591; JP 1990191281; US 4968794; US 5082839; US 5155103

Adefovir, GS-0393, GS-393, PMEA

阿德福韦Chemical Name: 9-[2-(Phosphonomethoxy)ethyl]adenine; [2-(6-Amino-9H-purin-9-yl)ethoxymethyl]phosphonic acid
CAS No. 106941-25-7, 118553-11-0 (monoNa salt)
项目整合开发状态: Registered
项目研究机构: Aca...
参考文献标题:Novel phosphonate nucleosides as antiviral agents
文献作者:Hwang,J.-T.; Choi,J.-R.
参考来源:Drugs Fut 2004,29(2),163

Adefovir dipivoxil, GS-840, Bis(pom)PMEA, Piv2PMEA, Hepsera, Preveon(former TM)

阿德福韦酯Chemical Name: 9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine
CAS No. 142340-99-6
项目整合开发状态: Launched-2002
项目研究机构: Inst. Organic Chemistry Biochemistry (Originator), Rega In...
参考文献标题:Prodrug of phosphonates
文献作者:Starrett,J.E.Jr.; Mansuri,M.M.; Martin,J.C.; Tortolani,D.R.; Bronson,J.J.(Bristol-Myers Squibb Co.)
参考来源:EP 0481214; JP 1992230694

Agomelatine, S-20098, Valdoxan

阿戈美拉汀Chemical Name: N-[2-(7-Methoxy-1-napthyl)ethyl]acetamide
CAS No. 138112-76-2
项目整合开发状态: Phase III
项目研究机构: Servier (Originator)
合成路线:Reformatskii reaction between 7-methoxy-1-tetralone ...
参考文献标题:Novel derivs.with a naphthalenic structure,their process of preparation and pharmaceutical compsns.containing them
文献作者:Andrieux,J.; Houssin,R.; Said,Y.; Guardiola-Lemaitre,B.; Lesieur,D.(ADIR et Cie.)
参考来源:EP 0447285; FR 2658819; JP 1995048331; US 5318994

Acitazanolast, MTCC, WP-871, Zepelin

阿扎司特Chemical Name: 3-(1H-Tetrazol-5-yl)oxanilic acid; N-[3-(1H-Tetrazol-5-yl)phenyl]oxamic acid; 2-Oxo-2-[3-(1H-tetrazol-5-yl)phenylamino]acetic acid
CAS No. 114607-46-4, 114607-48-6 (diNa salt), 1...
参考文献标题: 3-(1H-Tetrazol-5-yl)oxanilic acid and salts thereof,method for preparing the same and pharmacological compsns.Containing the cpd
文献作者:Sawaki,S.; Ootake,Y.; Hashimoto,T.; Abe,T.; Horio,Y.(Wakamoto Pharmaceutical Co.,Ltd.)
参考来源:EP 0256507; JP 1988044570; US 4795756

Ladakamycin(formerly), Azacitidine, U-18496, NSC-102816, Vidaza, Mylosar

阿扎胞苷Chemical Name: 5-Azacytidine; 4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 1-(beta-D-Ribofuranosyl)-5-azacytosine
CAS No. 320-67-2
项目整合开发状态: Launched-2004
项目研究机构: Pharmion (O...
参考文献标题:Nucleic acid components and their analogues.LI.Synthesis of 1-glycosyl derivatives of 5-azauracil and 5-azacytosine
文献作者:Sorm,F.; Piskala,A.
参考来源:Coll Czech Chem Commun 1964,292060-76

Atazanavir sulfate, BMS-232632-05, CGP-73547, BMS-232632(free base), Reyataz

阿扎那韦硫酸盐阿扎那韦 Chemical Name: N'-[2(S)-Hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]-Nalpha-(methoxycarbonyl)-N'-[4-(2-pyridyl)benzyl]-L-tert-leucylhydrazide sulfate salt (1:1) 参考文献标题:Antivirally active heterocyclic azahexane derivs.
文献作者:F鋝sler,A.; Bold,G.; Capraro,H.-G.; Lang,M.; Khanna,S.C.(Novartis AG)
参考来源:EP 0900210; JP 1999511177; US 5849911; WO 9740029

Atorvastatin calcium, YM-548, CI-981, Prevencor, Tahor, Lipibec, Torvast, Sortis, Lipitor

阿托伐他汀钙阿伐他汀阿伐他汀Chemical Name: (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt (2:1)
CAS No. 134523-03-8, 134523-00-5 (...
参考文献标题:Trans-6-[2-(3- or 4-carboxamido-substd.pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
文献作者:Roth,B.D.(Pfizer Inc.)
参考来源:EP 0247633; US 4681893

Atovaquone, BW-A566C, 566C80, Wellvone, Mepron

阿托伐醌 2-4-(4-氯苯)环己基-3-羟基-1,4-二氢萘-1,4-二氢萘-1,4-二酮 Chemical Name: 2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone
CAS No. 95233-18-4, 94015-53-9 (undefined stereoch.)
项目整合开发状态: L...