项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Astemizole, MJD-30, R-43512, Hismanal

阿司咪唑Chemical Name: 1-(4-Fluorobenzyl)-2-[1-(4-methoxyphenethyl)piperidin-4-ylamino]benzimidazole; 1-(4-Fluorobenzyl)-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]-1H-benzimidazol-2-amine
CAS No. 6...
参考文献标题:N-Heterocyclyl-4-piperidinamines
文献作者:Janssens,F.; Stokbroekx,R.; Torremans,J.; Luyckx,M.(Janssen Pharmaceutica NV)
参考来源:EP 0005318

Adinazolam, U-41123, Deracyn

阿地唑仑阿地唑仑甲磺酸盐 Chemical Name: 8-Chloro-N,N-dimethyl-6-phenyl-4H-[1,2-4]triazolo[4,3-a][1,4]benzodiazepine-1-methanamine; 8-Chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazep...
参考文献标题:Adinazolam
文献作者:Castar,J.; Pento,J.T.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1983,8(2),87

Asenapine maleate, Org-5222

阿塞那平马来酸盐阿塞那平 Chemical Name: trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate (1:1)
CAS No. 85650-56-2, 65576-45-6 (free base)
项目整合开发状态: Phase III 参考文献标题:The syntheses of radiolabelled Org 5222 and its main metabolite Org 30526
文献作者:Wagenaars,G.; Vader,J.; Sperling,E.; Terpstra,A.; Kaspersen,F.; Hilberink,P.; Schlachter,I.
参考来源:J Label Compd Radiopharm 1994,34(9),845

Auridine, CP-20961

阿夫立定Chemical Name: N,N-Dioctadecyl-N',N'-bis-(2-hydroxyethyl)propane-1,3-diamine; 2,2'-[[3-(Dioctadecylamino)propyl]imino]bis-ethanol
CAS No. 35607-20-6
项目整合开发状态: Preclinical
项目研究机构: Pfizer (...
参考文献标题:CP-20961
文献作者:Castar,J.; Sweetman,A.J.
参考来源:Drugs Fut 1979,4(3),189

Alpidem, SL-80.0342-00, Ananxyl

阿尔吡登Chemical Name: 6-Chloro-2-(4-chlorophenyl)-N,N-dipropylimidazo[1,2-a]pyridine-3-acetamide
CAS No. 82626-01-5
项目整合开发状态: Withdrawn-1993
项目研究机构: Sanofi-Aventis (Originator), Lorex (Licensee)...
参考文献标题:Imidazo[1,2-a] pyridine derivs.and their applicat
文献作者:George,P.; Kaplan,J.-P.(Sanofi-Synthabo )
参考来源:EP 0050563; US 4382938

Anipamil

阿尼帕米Chemical Name: alpha-Dodecyl-3-methoxy-alpha-[3-[N-[2-(3-methoxyphenyl)ethyl]-N-methylamino]propyl]benzeneacetonitrile; 2-[3-[N-[2-(3-Methoxyphenyl)ethyl]-N-methylamino]propyl]-2-(3-methoxyphenyl)...
参考文献标题:omega-Cyano-1,omega-diphenyl-azaalkiane derivatives,their preparation and drugs containing them
文献作者:Ehrmann,O.; et al.(BASF AG)
参考来源:DE 3144150

Anirolac, RS-37326

阿尼罗酸Chemical Name: (?-5-(4-Methoxybenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid; (?-2,3-Dihydro-5-(4-methoxybenzoyl)-1H-pyrrolizine-1-carboxylic acid; (?-5-p-Anisoyl-2,3-dihydro-1H-p...
参考文献标题:Imidazoyl-substd.thiomethylpyridine derivs.,method of administration thereof and medicaments containing them
文献作者:Engler,H.; Schickaneder,H.; Szelenyi,I.(Heumann Pharma GmbH & Co.)
参考来源:DE 3216843; EP 0093252; US 4810715

V-Echinocandin, Anidulafungin, VER-002, LY-303366

阿尼芬净Chemical Name: (11aS,25aS)-N-[9(S)-[1(S),2(S)-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-1(S),13(R),22(R),23(R)-tetrahydroxy-6(S),17(S)-bis[1(R)-hydroxyethyl]-2(S)-methyl-5,8,11,16,19,25-hexaoxoperhydrod...
参考文献标题:Cyclic peptide antifungal agents and process for preparation thereof
文献作者:Burkhardt,F.J.; Debono,M.; Nissen,J.S.; Turner,W.W.Jr.(Eli Lilly and Company)
参考来源:EP 0561639; JP 1994056892

Aniracetam, Ro-13-5057, Reset, Ampamet, Sarpul, Draganon

阿尼西坦Chemical Name: 1-p-Anisoyl-2-pyrrolidinone; 1-(4-Methoxybenzoyl)pyrrolidin-2-one
CAS No. 72432-10-1
项目整合开发状态: Launched-1993
项目研究机构: Roche (Originator), Biomedica Foscama (Licensee), Menar...
参考文献标题:1-(p-Methoxy-p-hydroxy,and p-benzyloxybenzoyl)-2-pyrrolidinones
文献作者:Kyburz,E.; Aschwanden,W.(F.Hoffmann-La Roche AG)
参考来源:DD 141828; EP 0005143; EP 0044088; ES 477587; ES 483756; JP 54117468

Albaconazole, UR-9825

阿巴康唑Chemical Name: (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one
CAS No. 187949-02-6
项目整合开发状态: Phase I
项目研究机构: Uriach (Ori...
参考文献标题:New pyrimidone derivs.with antifungal activity
文献作者:Bartrol? J.; Turmo,E.; Anguita,M.(J.Uriach & C韆.,SA)
参考来源:EP 0783501; ES 2107376; ES 2120885; JP 1998508317; US 5807854; WO 9705130