Aniracetam, Ro-13-5057, Reset, Ampamet, Sarpul, Draganon

阿尼西坦Chemical Name: 1-p-Anisoyl-2-pyrrolidinone; 1-(4-Methoxybenzoyl)pyrrolidin-2-one
CAS No. 72432-10-1
项目整合开发状态: Launched-1993
项目研究机构: Roche (Originator), Biomedica Foscama (Licensee), Menarini (Licensee), Toyama (Licensee)
合成路线:The silylation of 4-acetoxy-2-pyrrolidone (I) with trimethylchlorosilane (II) by means of triethyl amine in THF gives the corresponding N-trimethylsilyl derivative (III),which is condensed with 4-methoxybenzoyl chloride (IV) by means of NaHCO3 in THF yielding 1-(4-methoxybenzoyl)pyrrolin-2-one (V).Finally,this compound is reduced with H2 over Pd/C in ethyl acetate.

合成路线:The condensation of 4-aminobutyric acid (VI) with acid chloride (IV) by means of NaOH in water gives 4-(4-methoxybenzoylamino)butyric acid (VII),which is then cyclized by means of P2O5 in phosphoric acid.

合成路线:The condensation of 6-methoxy-2-naphthaldehyde (I) with acetone by means of NaOH in water gives 4-(6-methoxy-2-naphtyl)-3-buten-2-one (II),which is reduced with H2 over Pd/C in ethyl acetate.