合成路线:The condensation of 2-amino-4,5-dimethoxybenzonitrile (I) with 2-acetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (II) by means of POCl3 and dimethylacetamide in refluxing CHCl3 gives 2-[1-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethylideneamino]-4,5-dimethoxybenzonitrile (III),which is then cyclized with lithium diisopropylamide in THF at -70 C or with ZnCl2 in refluxing dimethylacetamide.
参考文献标题:A convenient synthesis of 2,4-diaminoquinoline derivatives
文献作者:Hardstone,J.D.; Palmer,M.J.A.; Campbell,S.F.
参考来源:Tetrahedron Lett 1984,25(42),4813
合成路线:The condensation of 2-amino-4,5-dimethoxybenzonitrile (I) with 2-acetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (II) by means of POCl3 and dimethylacetamide in refluxing CHCl3 gives 2-[1-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethylideneamino]-4,5-dimethoxybenzonitrile (III),which is then cyclized with lithium diisopropylamide in THF at -70 C or with ZnCl2 in refluxing dimethylacetamide.
参考文献标题:Abanoquil Mesylate
文献作者:Pento,J.T.
参考来源:Drugs Fut 1992,17(11),983
产品链接: CAS No. 118931-00-3›› 产品链接: CAS No.90402-40-7››