Azastene, Win-17625
阿查斯顿Chemical Name: 4,4,17-Trimethylandrosta-2,5-dieno[2,3-d]isoxazol--17beta-ol
CAS No. 13074-00-5
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of 4,4,17-trimethyl-17beta-hydroxy-5-androsten-3-one (I) with ethyl formate by means of sodium methoxide in benzene gives 4,4,17-trimethyl-17beta-hydroxy-2-hydroxymethylene-5-androsten-3-one (II),which is then cyclized with hydroxylamine hydrochloride by means of sodium acetate in refluxing acetic acid.
📌 参考资料/链接：
参考文献标题:
文献作者:Clinton,R.O.; Manson,A.J.
参考来源:US 3135743
📄 详细内容
合成路线:The reaction of 4,4,17-trimethyl-17beta-hydroxy-5-androsten-3-one (I) with ethyl formate by means of sodium methoxide in benzene gives 4,4,17-trimethyl-17beta-hydroxy-2-hydroxymethylene-5-androsten-3-one (II),which is then cyclized with hydroxylamine hydrochloride by means of sodium acetate in refluxing acetic acid.
参考文献标题:Azastene
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Sungurbey,K.; Hillier,K.
参考来源:Drugs Fut 1982,7(12),859
产品链接: CAS No. 13074-00-5››