合成路线:The estrification of L-trans-epoxysuccinic acid hemi-ethyl ester (I) with 4-nitrophenol (II) by means of dicyclohexylcarbodiimide (DCC) gives the corresponding p-nitrophenyl ester (III),which is then condensed with N-isoamyl L-leucinamide (IV).
合成路线:The synthesis of [14 C]-EST has been described ac cording to the following procedure:The oxidation of fumaric acid (I) with H2O2 gives trans-epoxysuccinic acid (II),which is submitted to optical resolution by means of its salt with L-arginine.The L-trans isomer (III) is esterified with ethanol and H2SO4 to the corresponding diethyl ester (IV),which is hydrolyzed selectively with KOH,affording the monoethyl ester (V).Finally,this monoester 5 condensed with N-isoamyl-L-leucinamide (VI).
参考文献标题:EST
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(11),927
合成路线:The synthesis of [14 C]-EST has been described ac cording to the following procedure:The oxidation of fumaric acid (I) with H2O2 gives trans-epoxysuccinic acid (II),which is submitted to optical resolution by means of its salt with L-arginine.The L-trans isomer (III) is esterified with ethanol and H2SO4 to the corresponding diethyl ester (IV),which is hydrolyzed selectively with KOH,affording the monoethyl ester (V).Finally,this monoester 5 condensed with N-isoamyl-L-leucinamide (VI).
参考文献标题:In vivo actions of EST (reort 1) - Absorption and excretion of 14C-EST
文献作者:Fukushima,K.; et al.
参考来源:Kiso To Rinsho 1986,20(4),319
产品链接: CAS No. 88321-09-9›› 产品链接: CAS No.96244-68-7››